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Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits
- Source :
- American Journal of Human Genetics, 100(6), 865-884. Cell Press, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, McCarthy, S, Crawford, A A, Bombieri, C, Cocca, M, Farmaki, A-E, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-Gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W-Y, Locke, A, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-Hansen, A, Varbo, A, Zoledziewska, M, Finan, C, Hatzikotoulas, K, Hendricks, A E, Kemp, J P, Moayyeri, A, Panoutsopoulou, K, Szpak, M, Wilson, S G, Boehnke, M, Cucca, F, Di Angelantonio, E, Langenberg, C, Lindgren, C, McCarthy, M I, Morris, A P, Nordestgaard, B G, Scott, R A, Tobin, M D, Wareham, N J, Burton, P, Chambers, J C, Smith, G D, Dedoussis, G, Felix, J F, Franco, O H, Gambaro, G, Gasparini, P, Hammond, C J, Hofman, A, Jaddoe, V W V, Kleber, M, Kooner, J S, Perola, M, Relton, C, Ring, S M, Rivadeneira, F, Salomaa, V, Spector, T D, Stegle, O, Toniolo, D, Uitterlinden, A G, Barroso, I, Greenwood, C M T, Perry, J R B, Walker, B R, Butterworth, A S, Xue, Y, Durbin, R, Small, K S, Soranzo, N, Timpson, N J, Zeggini, E & Bansal, N 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865-884 . https://doi.org/10.1016/j.ajhg.2017.04.014, The American Journal of Human Genetics, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, McCarthy, S, Crawford, A J, Bombieri, C, Cocca, M, Farmaki, A-E, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-Gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W-Y, Locke, A E, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-Hansen, A, Nordestgaard, B G & SpiroMeta Consortium 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865-884 . https://doi.org/10.1016/j.ajhg.2017.04.014, AMERICAN JOURNAL OF HUMAN GENETICS, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, Mccarthy, S, Crawford, A A, Bombieri, C, Cocca, M, Farmaki, A, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W, Locke, A, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-hansen, A, Varbo, A, Zoledziewska, M, Finan, C, Hatzikotoulas, K, Hendricks, A E, Kemp, J P, Moayyeri, A, Panoutsopoulou, K, Szpak, M, Wilson, S G, Boehnke, M, Cucca, F, Di Angelantonio, E, Langenberg, C, Lindgren, C, Mccarthy, M I, Morris, A P, Nordestgaard, B G, Scott, R A, Tobin, M D, Wareham, N J, Burton, P, Chambers, J C, Smith, G D, Dedoussis, G, Felix, J F, Franco, O H, Gambaro, G, Gasparini, P, Hammond, C J, Hofman, A, Jaddoe, V W V, Kleber, M, Kooner, J S, Perola, M, Relton, C, Ring, S M, Rivadeneira, F, Salomaa, V, Spector, T D, Stegle, O, Toniolo, D, Uitterlinden, A G, Barroso, I, Greenwood, C M T, Perry, J R B, Walker, B R, Butterworth, A S, Xue, Y, Durbin, R, Small, K S, Soranzo, N, Timpson, N J & Zeggini, E 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865-884 . https://doi.org/10.1016/j.ajhg.2017.04.014, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, McCarthy, S, Crawford, A A, Bombieri, C, Cocca, M, Farmaki, A-E, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-Gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W-Y, Locke, A, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-Hansen, A, Varbo, A, Zoledziewska, M, Finan, C, Hatzikotoulas, K, Hendricks, A E, Kemp, J P, Moayyeri, A, Panoutsopoulou, K, Szpak, M, Wilson, S G, Boehnke, M, Cucca, F, Di Angelantonio, E, Langenberg, C, Lindgren, C, McCarthy, M I, Morris, A P, Nordestgaard, B G, Scott, R A, Tobin, M D, Wareham, N J, Burton, P, Chambers, J C, Smith, G D, Dedoussis, G, Felix, J F, Franco, O H, Gambaro, G, Gasparini, P, Hammond, C J, Hofman, A, Jaddoe, V W V, Kleber, M, Kooner, J S, Perola, M, Relton, C, Ring, S M, Rivadeneira, F, Salomaa, V, Spector, T D, Stegle, O, Toniolo, D, Uitterlinden, A G, Barroso, I, Greenwood, C M T, Perry, J R B, Walker, B R, Butterworth, A S, Xue, Y, Durbin, R, Small, K S, Soranzo, N, Timpson, N J & Zeggini, E 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865–884 . https://doi.org/10.1016/j.ajhg.2017.04.014
- Publication Year :
- 2017
-
Abstract
- Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole genome sequencing (WGS) and deep imputation approach to examine the broader allelic architecture of twelve anthropometric traits associated with height, body mass and fat distribution in up to 267,616 individuals. We report 106 genome-wide significant signals that have not been previously identified, including 9 low-frequency variants pointing to functional candidates. Of the 106 signals, 6 are in genomic regions that have not been implicated with related traits before, 28 are independent signals at previously reported regions, and 72 represent previously reported signals for a different anthropometric trait. Seventy-one percent of signals reside within genes and fine-mapping resolves 23 signals to one or two likely causal variants. We confirm genetic overlap between human monogenic and polygenic anthropometric traits, and find signal enrichment in cis expression QTLs in relevant tissues. Our results highlight the potential of WGS strategies to enhance biologically-relevant discoveries across the frequency spectrum.
- Subjects :
- Male
0301 basic medicine
DXA trait
Lipodystrophy
next-generation whole-genome sequencing
GoT2D Consortium
LOCI
Genome-wide association study
imputation
anthropometry
DXA traits
genetic association study
UK Biobank
UK10K
Body Height
Cohort Studies
DNA Methylation
Databases, Genetic
Female
Genetic Variation
Humans
Meta-Analysis as Topic
Obesity
Physical Chromosome Mapping
Quantitative Trait Loci
Sequence Analysis, DNA
Sex Characteristics
Syndrome
United Kingdom
Anthropometry
Genome, Human
Genome-Wide Association Study
Genetics
Genetics (clinical)
Settore MED/03 - GENETICA MEDICA
DISEASE
HOMEOBOX GENE
WIDE ASSOCIATION
Genetics & Heredity
Genome
1184 Genetics, developmental biology, physiology
11 Medical And Health Sciences
RARE VARIANTS
OBESITY
LOW-FREQUENCY
Life Sciences & Biomedicine
Sequence Analysis
arcOGEN Consortium
Human
ADULT HUMAN HEIGHT
Understanding Society Scientific Group
Computational biology
TARGETED DISRUPTION
Quantitative trait locus
Biology
Article
Databases
03 medical and health sciences
Genetic
Genetic variation
Journal Article
UK10K Consortium
Allele
Genetic association
Whole genome sequencing
Science & Technology
SpiroMeta Consortium
DNA
06 Biological Sciences
Sex Characteristic
030104 developmental biology
Human genome
3111 Biomedicine
Cohort Studie
KNOCKOUT MICE
Imputation (genetics)
Subjects
Details
- Language :
- English
- ISSN :
- 00029297
- Database :
- OpenAIRE
- Journal :
- American Journal of Human Genetics, 100(6), 865-884. Cell Press, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, McCarthy, S, Crawford, A A, Bombieri, C, Cocca, M, Farmaki, A-E, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-Gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W-Y, Locke, A, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-Hansen, A, Varbo, A, Zoledziewska, M, Finan, C, Hatzikotoulas, K, Hendricks, A E, Kemp, J P, Moayyeri, A, Panoutsopoulou, K, Szpak, M, Wilson, S G, Boehnke, M, Cucca, F, Di Angelantonio, E, Langenberg, C, Lindgren, C, McCarthy, M I, Morris, A P, Nordestgaard, B G, Scott, R A, Tobin, M D, Wareham, N J, Burton, P, Chambers, J C, Smith, G D, Dedoussis, G, Felix, J F, Franco, O H, Gambaro, G, Gasparini, P, Hammond, C J, Hofman, A, Jaddoe, V W V, Kleber, M, Kooner, J S, Perola, M, Relton, C, Ring, S M, Rivadeneira, F, Salomaa, V, Spector, T D, Stegle, O, Toniolo, D, Uitterlinden, A G, Barroso, I, Greenwood, C M T, Perry, J R B, Walker, B R, Butterworth, A S, Xue, Y, Durbin, R, Small, K S, Soranzo, N, Timpson, N J, Zeggini, E & Bansal, N 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865-884 . https://doi.org/10.1016/j.ajhg.2017.04.014, The American Journal of Human Genetics, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, McCarthy, S, Crawford, A J, Bombieri, C, Cocca, M, Farmaki, A-E, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-Gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W-Y, Locke, A E, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-Hansen, A, Nordestgaard, B G & SpiroMeta Consortium 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865-884 . https://doi.org/10.1016/j.ajhg.2017.04.014, AMERICAN JOURNAL OF HUMAN GENETICS, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, Mccarthy, S, Crawford, A A, Bombieri, C, Cocca, M, Farmaki, A, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W, Locke, A, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-hansen, A, Varbo, A, Zoledziewska, M, Finan, C, Hatzikotoulas, K, Hendricks, A E, Kemp, J P, Moayyeri, A, Panoutsopoulou, K, Szpak, M, Wilson, S G, Boehnke, M, Cucca, F, Di Angelantonio, E, Langenberg, C, Lindgren, C, Mccarthy, M I, Morris, A P, Nordestgaard, B G, Scott, R A, Tobin, M D, Wareham, N J, Burton, P, Chambers, J C, Smith, G D, Dedoussis, G, Felix, J F, Franco, O H, Gambaro, G, Gasparini, P, Hammond, C J, Hofman, A, Jaddoe, V W V, Kleber, M, Kooner, J S, Perola, M, Relton, C, Ring, S M, Rivadeneira, F, Salomaa, V, Spector, T D, Stegle, O, Toniolo, D, Uitterlinden, A G, Barroso, I, Greenwood, C M T, Perry, J R B, Walker, B R, Butterworth, A S, Xue, Y, Durbin, R, Small, K S, Soranzo, N, Timpson, N J & Zeggini, E 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865-884 . https://doi.org/10.1016/j.ajhg.2017.04.014, Tachmazidou, I, Süveges, D, Min, J L, Ritchie, G R S, Steinberg, J, Walter, K, Iotchkova, V, Schwartzentruber, J, Huang, J, Memari, Y, McCarthy, S, Crawford, A A, Bombieri, C, Cocca, M, Farmaki, A-E, Gaunt, T R, Jousilahti, P, Kooijman, M N, Lehne, B, Malerba, G, Männistö, S, Matchan, A, Medina-Gomez, C, Metrustry, S J, Nag, A, Ntalla, I, Paternoster, L, Rayner, N W, Sala, C, Scott, W R, Shihab, H A, Southam, L, St Pourcain, B, Traglia, M, Trajanoska, K, Zaza, G, Zhang, W, Artigas, M S, Bansal, N, Benn, M, Chen, Z, Danecek, P, Lin, W-Y, Locke, A, Luan, J, Manning, A K, Mulas, A, Sidore, C, Tybjaerg-Hansen, A, Varbo, A, Zoledziewska, M, Finan, C, Hatzikotoulas, K, Hendricks, A E, Kemp, J P, Moayyeri, A, Panoutsopoulou, K, Szpak, M, Wilson, S G, Boehnke, M, Cucca, F, Di Angelantonio, E, Langenberg, C, Lindgren, C, McCarthy, M I, Morris, A P, Nordestgaard, B G, Scott, R A, Tobin, M D, Wareham, N J, Burton, P, Chambers, J C, Smith, G D, Dedoussis, G, Felix, J F, Franco, O H, Gambaro, G, Gasparini, P, Hammond, C J, Hofman, A, Jaddoe, V W V, Kleber, M, Kooner, J S, Perola, M, Relton, C, Ring, S M, Rivadeneira, F, Salomaa, V, Spector, T D, Stegle, O, Toniolo, D, Uitterlinden, A G, Barroso, I, Greenwood, C M T, Perry, J R B, Walker, B R, Butterworth, A S, Xue, Y, Durbin, R, Small, K S, Soranzo, N, Timpson, N J & Zeggini, E 2017, ' Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits ', American Journal of Human Genetics, vol. 100, no. 6, pp. 865–884 . https://doi.org/10.1016/j.ajhg.2017.04.014
- Accession number :
- edsair.doi.dedup.....204f2ad0000de30434091d05a9fc3854