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Timeline for development of autologous bone marrow infusion (ABMi) therapy and perspective for future stem cell therapy
- Source :
- Journal of gastroenterology. 47(5)
- Publication Year :
- 2012
-
Abstract
- Liver cirrhosis patients generally progress to liver failure. To cure this progressive disease, we developed a novel cell therapy using bone marrow cells; autologous bone marrow cell infusion (ABMi) therapy. We previously described the possible action mechanism of ABMi therapy in the cirrhotic liver, and showed the timeline and results of clinical studies of ABMi therapy. We have also carried out other clinical studies using bone marrow cells and granulocyte colony-stimulating factor. Here, we report a new randomized clinical trial to evaluate the effects of ABMi therapy. However, ABMi therapy may not be possible in patients who are unable to undergo general anesthesia; therefore, we have started to develop a next-generation stem cell therapy using cultured mesenchymal stem cells.
- Subjects :
- Liver Cirrhosis
medicine.medical_specialty
Cirrhosis
Carcinoma, Hepatocellular
medicine.medical_treatment
Splenectomy
Mesenchymal Stem Cell Transplantation
Cell therapy
Mice
Granulocyte Colony-Stimulating Factor
medicine
Animals
Humans
Bone Marrow Transplantation
business.industry
Mesenchymal stem cell
Liver Neoplasms
Gastroenterology
Stem-cell therapy
medicine.disease
Liver regeneration
Surgery
Liver Regeneration
Disease Models, Animal
medicine.anatomical_structure
Bone marrow
business
Progressive disease
Subjects
Details
- ISSN :
- 14355922
- Volume :
- 47
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....204d00ba9ad5c3fb9ea214d20cf758d8