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Safety and efficacy of anticoagulant therapy in pediatric catheter-related venous thrombosis (EINSTEIN-Jr CVC-VTE)

Authors :
Paola Saracco
Gili Kenet
Pascal Amedro
Christoph Male
Ildar Nurmeev
Cynthia Gauger
William T. Smith
M. Patricia Massicotte
Anthony K.C. Chan
Paul Monagle
Joyce Ching Mei Lam
Zeynep Karakas
Guy Young
Anthonie W. A. Lensing
Dagmar Kubitza
Scott D. Berkowitz
Damien Bonnet
Joseph S. Palumbo
Juan Chain
Takanari Ikeyama
Martin H. Prins
Akos F. Pap
Katharina Thom
Madhurima Majumder
Fanny Bajolle
Department of Paediatrics, Medical University of Vienna, Vienna
Bayer AG [Wuppertal, Germany]
Kazan State Medical University, Kazan
M3C-Necker Enfants Malades, Université Paris Descartes, Sorbonne Paris Cité, Paris
Tel Aviv University [Tel Aviv]
Israeli National Hemophilia Center and Thrombosis Unit and The Amalia Biron Thrombosis Research Institute, Sheba Medical Center, Tel Hashomer
Department of Pediatrics, University of Alberta, Edmonton, AB
Pediatric Hematology/Oncology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Pediatric Hematology, University Hospital Città della Salute e della Scienza, Turin
Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Hospital del Niño Jesus, San Miguel de Tucumán
McMaster Children's Hospital, Hamilton, ON
Aichi Children's Health and Medical Center, Aichi
Paediatric Haematology/Oncology Service, KK Women's and Children's Hospital, Singapore
Nemours Children's Specialty Care, Jacksonville, FL.
Bayer U.S., LLC, Whippany, NJ.
Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht
Department of Clinical Haematology, Royal Children's Hospital, Haematology Research Murdoch Children's Research Institute, Department of Paediatrics, University of Melbourne, Melbourne, VIC
Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA.
RS: CAPHRI - R5 - Optimising Patient Care
Epidemiologie
MUMC+: KIO Kemta (9)
Kazan State Medical University (KSMU)
Tel Aviv University (TAU)
University of Alberta
MORNET, Dominique
Source :
Blood Advances, Blood Advances, The American Society of Hematology, 2020, 4 (19), pp.4632-4639. ⟨10.1182/bloodadvances.2020002637⟩, Blood Adv, Blood advances, 4(19), 4632-4639. The American Society of Hematology, Blood Advances, 2020, 4 (19), pp.4632-4639. ⟨10.1182/bloodadvances.2020002637⟩
Publication Year :
2020
Publisher :
HAL CCSD, 2020.

Abstract

Anticoagulant treatment of pediatric central venous catheter–related venous thromboembolism (CVC-VTE) has not been specifically evaluated. In EINSTEIN-Jr, 500 children with any VTE received rivaroxaban or standard anticoagulants. A predefined analysis of the CVC-VTE cohort was performed. Children with CVC-VTE (age, birth to 17 years) were administered rivaroxaban or standard anticoagulants during the 1-month (children

Subjects

Subjects :
medicine.medical_specialty
CANADIAN REGISTRY
diagnosis
[SDV]Life Sciences [q-bio]
Hemorrhage
CHILDREN
030204 cardiovascular system & hematology
GUIDELINES
Asymptomatic
Thrombosis and Hemostasis
03 medical and health sciences
0302 clinical medicine
Rivaroxaban
Internal medicine
medicine
MANAGEMENT
Humans
cardiovascular diseases
Vein
Child
ComputingMilieux_MISCELLANEOUS
Venous Thrombosis
COMPLICATIONS
oral rivaroxaban
business.industry
Anticoagulants
Hematology
Odds ratio
thromboembolism
medicine.disease
equipment and supplies
Confidence interval
3. Good health
[SDV] Life Sciences [q-bio]
Catheter
Venous thrombosis
medicine.anatomical_structure
Cohort
medicine.symptom
business
030215 immunology
medicine.drug

Details

Language :
English
ISSN :
24739529 and 24739537
Database :
OpenAIRE
Journal :
Blood Advances, Blood Advances, The American Society of Hematology, 2020, 4 (19), pp.4632-4639. ⟨10.1182/bloodadvances.2020002637⟩, Blood Adv, Blood advances, 4(19), 4632-4639. The American Society of Hematology, Blood Advances, 2020, 4 (19), pp.4632-4639. ⟨10.1182/bloodadvances.2020002637⟩
Accession number :
edsair.doi.dedup.....2048afb63040667c051dee86c6747007
Full Text :
https://doi.org/10.1182/bloodadvances.2020002637⟩
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