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Cutaneous undifferentiated small (Merkel) cell carcinoma, that developed synchronously with multiple actinic keratoses, squamous cell carcinomas and basal cell carcinoma
- Source :
- The Journal of dermatology. 30(3)
- Publication Year :
- 2002
-
Abstract
- Merkel Cell Carcinoma (MCC) is an uncommon undifferentiated neuroendocrine tumor, arising in skin mainly on sun-exposed areas. We present an unusual case of primary cutaneous undifferentiated small cell carcinoma that co-existed with six other lesions; 2 actinic keratoses, 3 squmaous-cell carcinomas and a basal-cell carcinoma. HE stained sections revealed MCC located in the mid-dermis, co-existing with severe actinic keratosis. Immunohistochemically, the tumor cells reacted to cytokeratin 20, epithelial membrane antigen, chromogranin and neuron specific enolase. This is an unusual case of cutaneous MCC co-existing with six other different lesions. The concurrent development of MCC, squamous-cell and basal-cell carcinoma in the same patient indicates the pluripotent epidermal stem cell origin of these tumors. Further research is needed to enlighten the factors inducing this divergent differentiation.
- Subjects :
- Pathology
medicine.medical_specialty
Skin Neoplasms
Turkey
Cell
Dermatology
Small-cell carcinoma
Neoplasms, Multiple Primary
Cytokeratin
medicine
Carcinoma
Humans
Basal cell carcinoma
Aged
Neoplasm Staging
Aged, 80 and over
biology
Merkel cell carcinoma
business.industry
Actinic keratosis
Biopsy, Needle
food and beverages
Chromogranin A
General Medicine
Keratosis
medicine.disease
Immunohistochemistry
Carcinoma, Merkel Cell
medicine.anatomical_structure
Treatment Outcome
Carcinoma, Basal Cell
biology.protein
Carcinoma, Squamous Cell
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 03852407
- Volume :
- 30
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of dermatology
- Accession number :
- edsair.doi.dedup.....203991a242274c970f3d8176fa1aa453