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Mitochondria and Cardiovascular Disease: A Brief Account
- Source :
- Critical Reviews in Eukaryotic Gene Expression. 29:295-304
- Publication Year :
- 2019
- Publisher :
- Begell House, 2019.
-
Abstract
- Mitochondria represent the heart unit of the cardiac cell because they are involved in ATP production and in the transfer to the contractile apparatus. Furthermore, mitochondria modulate Ca2+ homeostasis, manage redox status, and regulate response to cellular and environmental stresses. Abnormalities in mitochondrial organelle structure and function have been observed in many cardiovascular diseases, such as ischemic cardiomyopathy, heart failure, and stroke, and in drug-induced cardiomyopathies. This review summarizes the recent literature in this field.
- Subjects :
- mitochondria, heart, cardiovascular disease
heart
Disease
Mitochondrion
Mitochondrial Membrane Transport Proteins
Models, Biological
03 medical and health sciences
Adenosine Triphosphate
cardiovascular disease
Genetics
Animals
Humans
Medicine
Molecular Biology
Stroke
0303 health sciences
Ischemic cardiomyopathy
Mitochondrial Permeability Transition Pore
business.industry
030302 biochemistry & molecular biology
medicine.disease
Redox status
Mitochondria
Electron Transport Chain Complex Proteins
Mitochondrial permeability transition pore
Cardiovascular Diseases
Heart failure
Calcium
Reactive Oxygen Species
business
Neuroscience
Homeostasis
Subjects
Details
- ISSN :
- 10454403
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Critical Reviews in Eukaryotic Gene Expression
- Accession number :
- edsair.doi.dedup.....2031fecdaf319b1ea97a798ff4abcc9c