Left ventricular ejection dynamics in hypertrophic cardiomyopathy and aortic stenosis: comparison with the use of Doppler echocardiography

Left ventricular ejection dynamics of 15 patients with hypertrophic cardiomyopathy (nine obstructive, six nonobstructive) were compared to those in 12 age-matched normal subjects and 10 patients with valvular aortic stenosis by means of combined two-dimensional and Doppler echocardiography. Doppler peak flow velocities in obstructive (HOCM, 2.5 +/- 1.3 m/sec) and nonobstructive (HNCM, 2.6 +/- 0.6 m/sec) hypertrophic cardiomyopathy, as well as in patients with aortic stenosis (AS, 3.6 +/- 1.3 m/sec) were significantly higher than in the normal population (1.0 +/- 0.2 m/sec; p less than 0.001 for all comparisons), but did not differ from each other. The HOCM patients had time to peak velocity (154 +/- 55.7 msec) that was higher than that in both HNCM (86 +/- 8.4 msec) and normal groups (84.5 +/- 8.9 msec; p less than 0.001 for both comparisons), but did not differ from those in AS (117 +/- 52.5 msec). The total ejection time did not differ between HOCM (348.2 +/- 91.1 msec) and AS (328.8 +/- 30.4 msec) groups, but was prolonged in HOCM compared to HNCM (198 +/- 21.0 msec) and normal groups (233 +/- 28.3 msec; p less than 0.001 for both comparisons). The normal and HNCM groups did not differ in time to peak or total ejection time measurements. The percent of flow velocity present in the initial third of the systolic velocity integral for HOCM (44.5% +/- 5.9) and HNCM (49.4% +/- 2.5) groups was greater than for normals (36.2% +/- 5.4; p less than 0.05 for both comparisons), but HOCM values did not differ from HNCM values.(ABSTRACT TRUNCATED AT 250 WORDS)