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Functional Imaging Using Fluorine (19F) MR Methods: Basic Concepts
- Source :
- Methods in Molecular Biology ISBN: 9781071609774, Methods Mol Biol
- Publication Year :
- 2021
- Publisher :
- Springer US, 2021.
-
Abstract
- Kidney-associated pathologies would greatly benefit from noninvasive and robust methods that can objectively quantify changes in renal function. In the past years there has been a growing incentive to develop new applications for fluorine (19F) MRI in biomedical research to study functional changes during disease states. 19F MRI represents an instrumental tool for the quantification of exogenous 19F substances in vivo. One of the major benefits of 19F MRI is that fluorine in its organic form is absent in eukaryotic cells. Therefore, the introduction of exogenous 19F signals in vivo will yield background-free images, thus providing highly selective detection with absolute specificity in vivo. Here we introduce the concept of 19F MRI, describe existing challenges, especially those pertaining to signal sensitivity, and give an overview of preclinical applications to illustrate the utility and applicability of this technique for measuring renal function in animal models.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.
- Subjects :
- Computer science
Renal function
Kidney
Machine learning
computer.software_genre
030218 nuclear medicine & medical imaging
Fluorine-19 Magnetic Resonance Imaging
03 medical and health sciences
0302 clinical medicine
In vivo
Image Processing, Computer-Assisted
medicine
Animals
Humans
Cost action
Monitoring, Physiologic
030304 developmental biology
0303 health sciences
business.industry
Fluorine
Functional imaging
medicine.anatomical_structure
Tissue oxygenation
Cardiovascular and Metabolic Diseases
Biomarker (medicine)
Artificial intelligence
Technology Platforms
business
computer
Biomarkers
Software
Research Article
Subjects
Details
- ISBN :
- 978-1-07-160977-4
- ISBNs :
- 9781071609774
- Database :
- OpenAIRE
- Journal :
- Methods in Molecular Biology ISBN: 9781071609774, Methods Mol Biol
- Accession number :
- edsair.doi.dedup.....200e07840fdadcb542a73a91e7ab0b45