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Molecular and spatial constraints on NB-LRR receptor signaling
- Source :
- Current Opinion in Plant Biology. 15:385-391
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- In plants, a large polymorphic family of intracellular NB-LRR receptors lies at the heart of robust resistance to diverse pathogens and mechanisms by which these versatile molecular switches operate in effector-triggered immunity are beginning to emerge. We outline recent advances in our understanding of NB-LRR receptor signaling leading to disease resistance. Themes covered are (i) NB-LRR molecular constraining forces and their intimate relationship with receptor activation in different parts of the cell, (ii) cooperativity between NB-LRR proteins and the formation of higher order NB-LRR signaling complexes, and (iii) the spatial separation of different resistance branches within cells. Finally, we examine evidence for dynamic signaling across cell compartments in coordinating diverse immune outputs.
- Subjects :
- Molecular switch
Protein Conformation
fungi
Cell
chemical and pharmacologic phenomena
Cooperativity
Plant Science
Plants
Biology
Leucine-Responsive Regulatory Protein
Cell biology
Immune system
Order (biology)
medicine.anatomical_structure
Protein structure
Host-Pathogen Interactions
medicine
Plant Immunity
Receptor
Intracellular
Disease Resistance
Signal Transduction
Subjects
Details
- ISSN :
- 13695266
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Plant Biology
- Accession number :
- edsair.doi.dedup.....200dccdd593f4cf2b60c60d843d3daf5