Back to Search
Start Over
Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma
- Source :
- Gynecologic Oncology, Hollis, R, Stanley, B, Iida, Y, Thomson, J, Churchman, M, Rye, T, Mackean, M J, Nussey, F, Gourley, C & Herrington, C S 2019, ' Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma ', Gynecologic Oncology, vol. 155, no. 2, pp. 318-323 . https://doi.org/10.1016/j.ygyno.2019.09.001, https://doi.org/10.1016/j.ygyno.2019.09.001
- Publication Year :
- 2019
- Publisher :
- Academic Press, 2019.
-
Abstract
- Background Numerous studies have investigated the association between hormone receptor expression and clinical outcome in ovarian carcinoma (OC); however, these have largely focussed on serous OCs, with few studies reporting specifically on endometrioid OCs (EnOC). Where analyses have been stratified by histotype, expression has been assessed using the percentage of positive tumor cells, without accounting for nuclear expression intensity. Methods Here we assess the expression levels of progesterone receptor (PR), estrogen receptor alpha (ER) and androgen receptor (AR) using histoscore – a nuclear scoring method incorporating both proportion of positive cells and the intensity of nuclear staining – across a cohort of 107 WT1 negative EnOCs. Results Hierarchical clustering by PR, ER and AR histoscores identified four EnOC subgroups (PR+/ER+, PR+/ER−, PR−/ER+ and PR−/ER−). EnOC patients in the PR+/ER+ and PR+/ER− groups displayed favorable outcome (multivariable HR for disease-specific survival 0.05 [0.01–0.35] and 0.05 [0.00–0.51]) compared to the PR−/ER+ group. Ten-year survival for stage II PRhigh and PRlow cases was 94.1% and 42.4%. ERhigh EnOC patients (PR+/ER+, PR−/ER+) had higher body mass index compared to ERlow cases (P = 0.015) and high grade serous OC patients (P<br />Highlights • We identify four subgroups of endometrioid ovarian carcinoma (EnOC) defined by hormone receptor expression patterns. • EnOC patients in the PRhigh (PR+/ER+, PR+/ER−) groups demonstrate markedly favorable outcome. • Stage II EnOC patients in the PRhigh groups display a ten-year survival of approximately 95%. • ERhigh (PR+/ER+, PR−/ER+) EnOC patients had a higher body mass index vs ERlow cases and high grade serous carcinoma patients.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Receptors, Progesterone/metabolism
Estrogen receptor
Receptors, Androgen/metabolism
Endometrioid ovarian carcinoma
Article
Progesterone receptor
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Ovarian cancer
Internal medicine
Ovarian carcinoma
Estrogen Receptor alpha/metabolism
medicine
Humans
Retrospective Studies
Ovarian Neoplasms
business.industry
Estrogen Receptor alpha
Obstetrics and Gynecology
Middle Aged
medicine.disease
Ovarian Neoplasms/metabolism
Androgen receptor
Serous fluid
030104 developmental biology
Hormone receptor
Receptors, Androgen
030220 oncology & carcinogenesis
Female
business
Receptors, Progesterone
Estrogen receptor alpha
Carcinoma, Endometrioid
Carcinoma, Endometrioid/metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 10956859 and 00908258
- Volume :
- 155
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Gynecologic Oncology
- Accession number :
- edsair.doi.dedup.....200b8cdaa79e130432ff75817701585f