Back to Search
Start Over
Simultaneous evaluation of perfusion and morphology using GRASP MRI in hepatic fibrosis
- Source :
- European radiology. 32(1)
- Publication Year :
- 2021
-
Abstract
- To determine if golden-angle radial sparse parallel (GRASP) dynamic contrast-enhanced (DCE)-MRI allows simultaneous evaluation of perfusion and morphology in liver fibrosis.Participants who were scheduled for liver biopsy or resection were enrolled (NCT02480972). Images were reconstructed at 12-s temporal resolution for morphologic assessment and at 3.3-s temporal resolution for quantitative evaluation. The image quality of the morphologic images was assessed on a four-point scale, and the Liver Imaging Reporting and Data System score was recorded for hepatic observations. Comparisons were made between quantitative parameters of DCE-MRI for the different fibrosis stages, and for hepatocellular carcinoma (HCCs) with different LR features.DCE-MRI of 64 participants (male = 48) were analyzed. The overall image quality consistently stood at 3.5 ± 0.4 to 3.7 ± 0.4 throughout the exam. Portal blood flow significantly decreased in participants with F2-F3 (n = 18, 175 ± 110 mL/100 mL/min) and F4 (n = 12, 98 ± 47 mL/100 mL/min) compared with those in participants with F0-F1 (n = 34, 283 ± 178 mL/100 mL/min, p0.05 for all). In participants with F4, the arterial fraction and extracellular volume were significantly higher than those in participants with F0-F1 and F2-F3 (p0.05). Compared with HCCs showing non-LR-M features (n = 16), HCCs with LR-M (n = 5) had a significantly prolonged mean transit time and lower arterial blood flow (p0.05).Liver MRI using GRASP obtains both sufficient spatial resolution for confident diagnosis and high temporal resolution for pharmacokinetic modeling. Significant differences were found between the MRI-derived portal blood flow at different hepatic fibrosis stages.A single MRI examination is able to provide both images with sufficient spatial resolution for anatomic evaluation and those with high temporal resolution for pharmacokinetic modeling. Portal blood flow was significantly lower in clinically significant hepatic fibrosis and mean transit time and extracellular volume increased in cirrhosis, compared with those in no or mild hepatic fibrosis. HCCs with different LR features showed different quantitative parameters of DCE-MRI: longer mean transit time and lower arterial flow were observed in HCCs with LR-M features.
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Contrast Media
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Fibrosis
Carcinoma
Medicine
Humans
Radiology, Nuclear Medicine and imaging
medicine.diagnostic_test
business.industry
Ultrasound
Liver Neoplasms
Magnetic resonance imaging
General Medicine
medicine.disease
Magnetic Resonance Imaging
Perfusion
030220 oncology & carcinogenesis
Liver biopsy
Hepatocellular carcinoma
Radiology
business
Hepatic fibrosis
Nuclear medicine
Subjects
Details
- ISSN :
- 14321084 and 02480972
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- European radiology
- Accession number :
- edsair.doi.dedup.....2000ffe854447a5645723e6f9be08196