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Minocycline attenuates cognitive impairment induced by isoflurane anesthesia in aged rats
- Source :
- PLoS ONE, Vol 8, Iss 4, p e61385 (2013), PLoS ONE
- Publication Year :
- 2013
- Publisher :
- Public Library of Science (PLoS), 2013.
-
Abstract
- Postoperative cognitive dysfunction (POCD) is a clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery, especially in geriatric surgical patients. Although it has been documented that isoflurane exposure impaired cognitive function in several aged animal models, there are few clinical interventions and treatments available to prevent this disorder. Minocycline has been well established to exert neuroprotective effects in various experimental animal models and neurodegenerative diseases. Therefore, we hypothesized that pretreatment with minocycline attenuates isoflurane-induced cognitive decline in aged rats. In the present study, twenty-month-old rats were administered minocycline or an equal volume of saline by intraperitoneal injection 12 h before exposure to isoflurane. Then the rats were exposed to 1.3% isoflurane for 4 h. Two weeks later, spatial learning and memory of the rats were examined using the Morris Water Maze. We found that pretreatment with minocycline mitigated isoflurane-induced cognitive deficits and suppressed the isoflurane-induced excessive release of IL-1β and caspase-3 in the hippocampal CA1 region at 4 h after isoflurane exposure, as well as the number of TUNEL-positive nuclei. In addition, minocycline treatment also prevented the changes of synaptic ultrastructure in the hippocampal CA1 region induced by isoflurane. In conclusion, pretreatment with minocycline attenuated isoflurane-induced cognitive impairment in aged rats.
- Subjects :
- Male
Aging
medicine.medical_treatment
Interleukin-1beta
Morris water navigation task
lcsh:Medicine
Apoptosis
Minocycline
Toxicology
Rats, Sprague-Dawley
Learning and Memory
Anesthesiology
Heart Rate
Hippocampus (mythology)
Anesthesia
Cognitive decline
lcsh:Science
Multidisciplinary
Isoflurane
Caspase 3
Animal Models
Medicine
Public Health
Research Article
medicine.drug
Drugs and Devices
Drug Research and Development
Cognitive Neuroscience
Intraperitoneal injection
Neuroprotection
Model Organisms
medicine
Animals
Arterial Pressure
Maze Learning
Biology
CA1 Region, Hippocampal
Tumor Necrosis Factor-alpha
business.industry
lcsh:R
medicine.disease
Rats
Pharmacodynamics
Geriatrics
Synapses
Rat
lcsh:Q
Cognition Disorders
business
Postoperative cognitive dysfunction
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....1ff15cf7207908b3f8eac30b92d67aed