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Does menthol cigarette use moderate the effect of nicotine metabolism on short-term smoking cessation?
- Source :
- Experimental and Clinical Psychopharmacology. 25:216-222
- Publication Year :
- 2017
- Publisher :
- American Psychological Association (APA), 2017.
-
Abstract
- The nicotine metabolite ratio (NMR) has been shown to predict response to the transdermal nicotine patch, such that faster nicotine metabolism is associated with a lower abstinence rate. Menthol cigarette use, versus nonmenthol cigarette use, slows nicotine metabolism and therefore may attenuate the effect of NMR on smoking abstinence. In this study, we evaluated whether cigarette type (menthol vs. nonmenthol) modified the association between NMR and short-term abstinence. This was a secondary analysis examining treatment in the first 8 weeks of 21 mg/day nicotine patch therapy in a completed clinical trial (n = 474). Menthol cigarette use was based on self-report. NMR was defined dichotomously (0 = fast, 1 = slow) to distinguish between fast (≥0.47) versus slow NMR. Using logistic regression analysis, we tested whether cigarette type moderated the association between NMR and bioverified 7-day point prevalence abstinence at Week 8. Covariates include nicotine dependence, age, race, and gender. Three hundred two participants reported smoking menthol cigarettes, of which 234 (77%) were classified as slow NMR. Among the 172 nonmenthol smokers, 136 were classified as slow NMR (79%). Contrary to our expectations, the NMR ×Cigarette Type interaction effect on abstinence was not significant (odds ratio [OR] = 0.91, p = .86). Excluding the interaction variable, fast NMR was associated with decreased likelihood of abstinence (OR = 0.55, p = .03), but menthol cigarette use was not (OR = 1.15, p = .56). Further exploration of risk factors among menthol cigarette smokers, especially among racially diverse and light smokers, could clarify the association between menthol cigarette use and poorer smoking outcomes. (PsycINFO Database Record
- Subjects :
- Adult
Male
Nicotine
Time Factors
Nicotine patch
medicine.medical_treatment
media_common.quotation_subject
Physiology
Smoking Prevention
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine
Humans
Pharmacology (medical)
030212 general & internal medicine
Pack-year
media_common
Pharmacology
business.industry
Tobacco Products
Tobacco Use Disorder
Odds ratio
Middle Aged
Abstinence
Tobacco Use Cessation Devices
Drug Abstinence
Menthol
Psychiatry and Mental health
Logistic Models
chemistry
Smoking cessation
Female
Smoking Cessation
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 19362293 and 10641297
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Experimental and Clinical Psychopharmacology
- Accession number :
- edsair.doi.dedup.....1fe562db644e4a76cb67cd6fb5694ead