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Targeting Toll-like receptors for treatment of SLE
- Source :
- Mediators of Inflammation, Mediators of Inflammation, Vol 2010 (2010)
- Publication Year :
- 2009
-
Abstract
- Toll-like receptors (TLRs) are important innate immune receptors for the identification and clearance of invading pathogens. Twelve TLRs that recognize various conserved components of microorganisms are currently known. Among these, the endosomal TLRs 3, 7/8, and 9 recognize dsRNA, ssRNA, and CpG DNA, respectively. Nucleic acid-sensing TLRs, TLR 7 in particular, have been implicated in systemic lupus erythematosus (SLE) and are thought to exacerbate disease pathology. Activation of these TLRs results in the production of inflammatory cytokines and type I interferon. Genome-wide association studies, single nucleotide polymorphism analyses as well as experimental mouse models have provided evidence of TLR signaling involvement in SLE and other autoimmune diseases. Since activation of these receptor pathways promotes autoimmune phenotypes, inhibitory drugs that target these pathways constitute important new therapeutic strategies for the treatment of systemic autoimmunity.
- Subjects :
- Immunology
Disease
Review Article
Biology
Models, Biological
Proinflammatory cytokine
Autoimmune Diseases
Mice
Interferon
medicine
lcsh:Pathology
Animals
Humans
Lupus Erythematosus, Systemic
Receptor
Innate immune system
Lupus erythematosus
Toll-Like Receptors
Cell Biology
medicine.disease
Phenotype
CpG site
medicine.drug
lcsh:RB1-214
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14661861
- Volume :
- 2010
- Database :
- OpenAIRE
- Journal :
- Mediators of inflammation
- Accession number :
- edsair.doi.dedup.....1fe09646f4e103d511204412295a3985