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A human stool-derived Bilophila wadsworthia strain caused systemic inflammation in specific-pathogen-free mice
- Source :
- Gut Pathogens, Gut Pathogens, Vol 9, Iss 1, Pp 1-10 (2017)
- Publication Year :
- 2017
- Publisher :
- BioMed Central, 2017.
-
Abstract
- Background Bilophila wadsworthia is a major member of sulfidogenic bacteria in human gut, it was originally recovered from different clinical specimens of intra-abdominal infections and recently was reported potentially linked to different chronic metabolic disorders. However, there is still insufficient understanding on its detailed function and mechanism to date. Methods A B. wadsworthia strain was isolated from fresh feces of a latent autoimmune diabetes in adults patient and we investigated its pathogenicity by oral administration to specific-pathogen-free mice. Tissue samples and serum were collected after sacrifice. Stool samples were collected at different time points to profile the gut microbiota. Results Bilophila wadsworthia infection resulted in the reduction of body weight and fat mass, apparent hepatosplenomegaly and elevated serum inflammatory factors, including serum amyloid A and interleukin-6, while without significant change of the overall gut microbiota structure. Conclusions These results demonstrated that higher amount of B. wadsworthia caused systemic inflammatory response in SPF mice, which adds new evidence to the pathogenicity of this bacterium and implied its potential role to the chronic inflammation related metabolic diseases like diabetes.
- Subjects :
- 0301 basic medicine
030106 microbiology
Hepatosplenomegaly
Inflammation
Gut microbiota
Gut flora
Systemic inflammation
Microbiology
03 medical and health sciences
Mice
Virology
medicine
Serum amyloid A
lcsh:RC799-869
Feces
Specific-pathogen-free
biology
Research
Gastroenterology
Bilophila wadsworthia
biology.organism_classification
030104 developmental biology
Infectious Diseases
Immunology
Parasitology
lcsh:Diseases of the digestive system. Gastroenterology
medicine.symptom
Subjects
Details
- Language :
- English
- ISSN :
- 17574749
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Gut Pathogens
- Accession number :
- edsair.doi.dedup.....1fd3b1cd39aec3581d1d4eead53bb2e3