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Selexipag for the treatment of chronic thromboembolic pulmonary hypertension
- Source :
- The European respiratory journal. 60(1)
- Publication Year :
- 2021
-
Abstract
- BackgroundTreatment options for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) remain limited. Selexipag, an oral selective IP prostacyclin receptor agonist approved for pulmonary arterial hypertension, is a potential treatment option for CTEPH.MethodsIn this multicentre, randomised, double-blind, placebo-controlled study, 78 Japanese patients with inoperable CTEPH or persistent/recurrent pulmonary hypertension after pulmonary endarterectomy and/or balloon pulmonary angioplasty were randomly assigned to receive placebo or selexipag. The primary end-point was the change in pulmonary vascular resistance (PVR) from baseline to week 20. Secondary end-points were changes in other haemodynamic parameters: 6-min walk distance (6MWD), Borg dyspnoea scale score, World Health Organization (WHO) functional class, EuroQol five-dimension five-level tool and N-terminal pro-brain natriuretic peptide.ResultsThe change in PVR was −98.2±111.3 dyn·s·cm−5 and −4.6±163.6 dyn·s·cm−5 in the selexipag and placebo groups, respectively (mean difference −93.5 dyn·s·cm−5; 95% CI −156.8 to −30.3; p=0.006). The changes in cardiac index (pConclusionSelexipag significantly improved PVR and other haemodynamic variables in patients with CTEPH, although exercise capacity remained unchanged. Further large-scale investigation is necessary to prove the role of selexipag in CTEPH.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
medicine.medical_treatment
Hypertension, Pulmonary
Cardiac index
Selexipag
Placebo
chemistry.chemical_compound
Internal medicine
Angioplasty
Acetamides
medicine
Clinical endpoint
Humans
Adverse effect
Antihypertensive Agents
business.industry
medicine.disease
Pulmonary hypertension
medicine.anatomical_structure
Dyspnea
Treatment Outcome
chemistry
Pyrazines
Chronic Disease
Vascular resistance
Cardiology
business
Pulmonary Embolism
Subjects
Details
- ISSN :
- 13993003
- Volume :
- 60
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The European respiratory journal
- Accession number :
- edsair.doi.dedup.....1fd32c0088010af0cfe15db28d0dec89