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Anticipating control over aversive stimuli is mediated by the medial prefrontal cortex: An fMRI study with healthy adults
- Source :
- Human Brain Mapping
- Publication Year :
- 2021
-
Abstract
- The anticipation of control over aversive events in life is relevant for our mental health. Insights on the underlying neural mechanisms remain limited. We developed a new functional magnetic resonance imaging (fMRI) task that uses auditory stimuli to explore the neural correlates of (1) the anticipation of control over aversion and (2) the processing of aversion. In a sample of 25 healthy adults, we observed increased neural activation in the medial prefrontal cortex (ventromedial prefrontal cortex and rostral anterior cingulate cortex), other brain areas relevant for reward anticipation (ventral striatum, brainstem [ventral tegmental area], midcingulate cortex), and the posterior cingulate cortex when they anticipated control over aversion compared with anticipating no control (1). The processing of aversive sounds compared to neutral sounds (2) was associated with increased neural activation in the bilateral posterior insula. Our findings provide evidence for the important role of medial prefrontal regions in control anticipation and highlight the relevance of conceiving the neural mechanisms involved within a reward‐based framework.<br />The anticipation of control over aversive events in life is relevant for our mental health. In healthy adults, control anticipation over aversive sounds is associated with increased neural activation in the medial prefrontal cortex and other brain areas relevant for reward anticipation.
- Subjects :
- Adult
Male
Prefrontal Cortex
616.8: Neurologie und Krankheiten des Nervensystems
610 Medicine & health
Gyrus Cinguli
Humans
2741 Radiology, Nuclear Medicine and Imaging
aversion
Insular Cortex
Research Articles
3614 Radiological and Ultrasound Technology
Brain Mapping
Ventral Tegmental Area
control anticipation
Middle Aged
10058 Department of Child and Adolescent Psychiatry
Anticipation, Psychological
2702 Anatomy
Magnetic Resonance Imaging
functional magnetic resonance imaging
10057 Klinik für Konsiliarpsychiatrie und Psychosomatik
2728 Neurology (clinical)
10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics
2808 Neurology
Ventral Striatum
Auditory Perception
Female
Psychomotor Performance
medial prefrontal cortex
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Human Brain Mapping
- Accession number :
- edsair.doi.dedup.....1fc9ff2937f63cd1d6d5728f3d777cd1