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Survey of the antimicrobial resistance of Helicobacter pylori in France in 2018 and evolution during the previous 5 years
- Source :
- Helicobacter, Helicobacter, Wiley, 2020, pp.e12767. ⟨10.1111/hel.12767⟩
- Publication Year :
- 2020
-
Abstract
- International audience; Background and objectives: Surveillance of Helicobacter pylori resistance to antibiotics was carried out in France in 2014, 2016, and 2018. We report here the results of the 2018 survey as well as the evolution over the 5-year period.Materials and methods: In this observational study, gastric biopsies were obtained by 62 gastroenterologists randomly selected in 5 regions of France and sent to a central laboratory where culture, antimicrobial susceptibility testing, and a real-time PCR were performed in order to detect H pylori and its mutations associated with clarithromycin resistance.Results and conclusion: During the year 2018, 951 patients were included: 55.3% women, mean age: 52.4 years ± 15.7, 71.6% born in France. Among them, 359 patients were H pylori positive by both culture and real-time PCR, and 7 more by PCR only. There were 244 naive patients, 110 previously treated patients, and unknown for 5. Primary resistance to clarithromycin was 20.9% [16.3-26.4], to levofloxacin 17.6% [13.4-22.9], and to metronidazole 58.6% [52.3%-64.6%]. Secondary resistance for these antibiotics was 56.4%, 22.7%, and 87.3%, respectively. There was no resistance to amoxicillin and tetracycline and very low resistance to rifampicin (1.2%) in both naive and treated patients. Primary resistance to clarithromycin decreased from 22.2% to 20.3% between 2014 and 2016, and appears to be stable since then. This can be linked to a stable consumption of macrolides over the 3-year time period. Primary levofloxacin resistance was relatively stable while metronidazole resistance increased. Interestingly, in both naive and treated patients, amoxicillin and rifampicin resistance were rare.
- Subjects :
- Male
[SDV]Life Sciences [q-bio]
Antibiotics
Gastroenterology
0302 clinical medicine
Levofloxacin
Clarithromycin
biology
General Medicine
Middle Aged
3. Good health
Anti-Bacterial Agents
[SDV] Life Sciences [q-bio]
Infectious Diseases
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
France
Rifampin
real-time PCR
medicine.drug
Adult
medicine.medical_specialty
medicine.drug_class
Microbial Sensitivity Tests
Helicobacter Infections
03 medical and health sciences
Antibiotic resistance
Internal medicine
Metronidazole
Drug Resistance, Bacterial
medicine
Humans
primary resistance
[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology
Aged
levofloxacin
Helicobacter pylori
business.industry
Amoxicillin
biology.organism_classification
culture
business
Rifampicin
Subjects
Details
- ISSN :
- 15235378 and 10834389
- Volume :
- 26
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- HelicobacterREFERENCES
- Accession number :
- edsair.doi.dedup.....1fc9aea5558df9a3c80af37fd21c2302