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Multicenter Investigation of Gepotidacin (GSK2140944) Agar Dilution Quality Control Determinations for Neisseria gonorrhoeae ATCC 49226
- Source :
- Antimicrobial Agents and Chemotherapy. 60:4404-4406
- Publication Year :
- 2016
- Publisher :
- American Society for Microbiology, 2016.
-
Abstract
- Gepotidacin, a novel triazaacenaphthylene antibacterial agent, is the first in a new class of type IIA topoisomerase inhibitors with activity against many biothreat and conventional pathogens, including Neisseria gonorrhoeae . To assist ongoing clinical studies of gepotidacin to treat gonorrhea, a multilaboratory quality assurance investigation determined the reference organism ( N. gonorrhoeae ATCC 49226) quality control MIC range to be 0.25 to 1 μg/ml (88.8% of gepotidacin MIC results at the 0.5 μg/ml mode).
- Subjects :
- 0301 basic medicine
Gepotidacin
Topoisomerase Inhibitors
medicine.drug_class
030106 microbiology
Gonorrhea
Microbial Sensitivity Tests
medicine.disease_cause
Agar dilution
Microbiology
03 medical and health sciences
Medicine
Pharmacology (medical)
Antibacterial agent
Pharmacology
Acenaphthenes
business.industry
medicine.disease
Neisseria gonorrhoeae
Anti-Bacterial Agents
030104 developmental biology
Infectious Diseases
Susceptibility
business
Heterocyclic Compounds, 3-Ring
Topoisomerase inhibitor
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....1fb6132bbbf7a08b404bc37fde0b0d44