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Results of two consecutive treatment protocols in Polish children with acute lymphoblastic leukemia
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
- Publication Year :
- 2020
-
Abstract
- The aim of the study was to retrospectively compare the effectiveness of the ALL IC-BFM 2002 and ALL IC-BFM 2009 protocols and the distribution of risk groups by the two protocols after minimal residual disease (MRD) measurement as well as its impact on survival. We reviewed the medical records of 3248 patients aged 1–18 years with newly diagnosed ALL who were treated in 14 hemato-oncological centers between 2002 and 2018 in Poland. The overall survival (OS) of 1872 children with ALL treated with the ALL IC 2002 protocol was 84% after 3 years, whereas the OS of 1376 children with ALL treated with the ALL IC 2009 protocol was 87% (P P = 0.006). Our study shows that the ALL IC-BFM 2009 protocol improved the results of children with ALL compared to the ALL IC-BFM 2002 protocol in Poland. This analysis confirms that MRD marrow assessment on day 15 of treatment by FCM-MRD is an important predictive factor.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Neoplasm, Residual
Lymphoblastic Leukemia
Fusion Proteins, bcr-abl
lcsh:Medicine
Newly diagnosed
Article
03 medical and health sciences
0302 clinical medicine
Risk groups
Clinical Protocols
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Overall survival
Medicine
Asparaginase
Humans
lcsh:Science
Child
Cancer
Retrospective Studies
Multidisciplinary
business.industry
Medical record
Incidence
lcsh:R
Daunorubicin
Antineoplastic Protocols
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Minimal residual disease
Progression-Free Survival
Predictive factor
030104 developmental biology
Treatment Outcome
Oncology
Risk factors
Vincristine
030220 oncology & carcinogenesis
Child, Preschool
Prednisone
lcsh:Q
Female
Poland
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
- Accession number :
- edsair.doi.dedup.....1f998a1f6d998a26fb4ab3ae653673fd