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The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
- Source :
- Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018), Scientific Reports
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Different microRNAs are dysregulated in ovarian cancer where some of them have proved to be valid biomarkers. miRNA profiling analyses have shown that the different histotypes of ovarian carcinoma display differential expression of specific miRNAs. In the present study, we used miRNA-sequencing and Real-Time qPCR to detect the expression levels of miRNAs belonging to the miRNA-192/215 family, namely miR-192, miR-194, and miR-215, in different types of ovarian neoplasia, finding that miR-192, miR-194, and miR-215 were upregulated in ovarian carcinomas of the mucinous subtype, but downregulated in other types of carcinoma and in sex cord-stromal tumors. The expression of the said miRNAs was 6-fold higher in mucinous tumors compared to the other histotypes making them candidates for a possible role as diagnostic biomarkers.
- Subjects :
- 0301 basic medicine
lcsh:Medicine
Biology
Article
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Ovarian carcinoma
microRNA
Carcinoma
medicine
Humans
lcsh:Science
Ovarian Neoplasms
Regulation of gene expression
Multidisciplinary
Gene Expression Profiling
lcsh:R
medicine.disease
Adenocarcinoma, Mucinous
Gene Expression Regulation, Neoplastic
Gene expression profiling
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Adenocarcinoma
Female
lcsh:Q
Ovarian cancer
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....1f9357ff1b484fb44426bfb771e1c786