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Effectiveness of cognitive remediation in depression: a meta-analysis
- Source :
- Psychological Medicine, 1-16. Cambridge University Press, STARTPAGE=1;ENDPAGE=16;ISSN=0033-2917;TITLE=Psychological Medicine, Psychological medicine. Cambridge University Press
- Publication Year :
- 2021
- Publisher :
- Cambridge University Press (CUP), 2021.
-
Abstract
- BackgroundPreliminary evidence suggests beneficial effects of cognitive remediation in depression. An update of the current evidence is needed. The aim was to systematically assess the effectiveness of cognitive remediation in depression on three outcomes.MethodsThe meta-analysis was pre-registered on PROSPERO (CRD42019124316). PubMed, PsycINFO, Embase and Cochrane Library were searched on 2 February 2019 and 8 November 2020 for peer-reviewed published articles. We included randomized and non-randomized clinical trials comparing cognitive remediation to control conditions in adults with primary depression. Random-effects models were used to calculate Hedges' g, and moderators were assessed using mixed-effects subgroup analyses and meta-regression. Main outcome categories were post-treatment depressive symptomatology (DS), cognitive functioning (CF) and daily functioning (DF).ResultsWe identified 5221 records and included 21 studies reporting on 24 comparisons, with 438 depressed patients receiving cognitive remediation and 540 patients in a control condition. We found a small effect on DS (g = 0.28, 95% CI 0.09–0.46, I2 40%), a medium effect on CF (g = 0.60, 95% CI 0.37–0.83, I2 44%) and a small effect on DF (g = 0.22, 95% CI 0.06–0.39, I2 3%). There were no significant effects at follow-up. Confounding bias analyses indicated possible overestimation of the DS and DF effects in the original studies.ConclusionsCognitive remediation in depression improves CF in the short term. The effects on DS and DF may have been overestimated. Baseline depressive symptom severity should be considered when administering cognitive remediation.
- Subjects :
- relapse
recurrence
major depressive disorder
business.industry
daily functioning
Confounding
depressive symptomatology
Cochrane Library
medicine.disease
cognitive functioning
Cognitive training
cognitive training
Psychiatry and Mental health
Cognitive remediation therapy
Meta-analysis
depression
medicine
Major depressive disorder
Cognitive remediation
Cognitive skill
business
Applied Psychology
Depression (differential diagnoses)
cognitive impairment
Clinical psychology
Subjects
Details
- ISSN :
- 14698978 and 00332917
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Psychological Medicine
- Accession number :
- edsair.doi.dedup.....1f885065d3a3a8cb3a200b22c056f7eb