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Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance
- Source :
- PPAR Research, Vol 2018 (2018), PPAR Research
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPARγin the coronary arteriole as a possible mechanism underlying vascular remodeling. Rats were treated with standard rodent chow (Control) or diet enriched in methionine (Met) for 48 weeks. Plasma homocysteine, blood glucose, serum lipids, malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) levels were measured. Coronary arteriolar and carotid arterial remodeling was assessed by histomorphometric techniques and the expression of PPARγin vessel wall was investigated. In Met group, an increase in the level of fasting blood glucose, serum triglyceride, total cholesterol, MDA, and NO, a decline in the serum SOD level, and increased collagen deposition in coronary and carotid arteries were found. Moreover, we detected decreased expression of PPARγin the coronary arterioles in Met group. In summary, our study revealed metabolic disturbances in this model of long-term hyperhomocysteinemia together with vascular remodeling and suggested that impaired oxidative stress, endothelium dysfunction, and decreased PPARγexpression in the vessel wall could be underlying mechanisms.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Hyperhomocysteinemia
Article Subject
Endothelium
medicine.disease_cause
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Arteriole
medicine.artery
Internal medicine
Drug Discovery
medicine
Pharmacology (medical)
lcsh:QH301-705.5
Vascular disease
business.industry
medicine.disease
Malondialdehyde
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
lcsh:Biology (General)
cardiovascular system
Metabolic syndrome
business
030217 neurology & neurosurgery
Oxidative stress
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 16874765 and 16874757
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- PPAR Research
- Accession number :
- edsair.doi.dedup.....1f7612cdff234763dddaad4621aafda0