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The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish
- Source :
- The Science of the total environment. 776
- Publication Year :
- 2020
-
Abstract
- Fluorene-9-bisphenol (BHPF) is a bisphenol A substitute, which has been introduced for the production of so-called ‘bisphenol A (BPA)-free’ plastics. However, it has been reported that BHPF can enter living organisms through using commercial plastic bottles and cause adverse effects. To date, the majority of the toxicologic study of BHPF focused on investigating its doses above the toxicological threshold. Here, we studied the effects of BHPF on development, locomotion, neuron differentiation of the central nervous system (CNS), and the expression of genes in the hypothalamic-pituitary-thyroid (HPT) axis in zebrafish exposed to different doses of BHPF ranging from 1/5 of LD1 to LD50 (300, 500, 750, 1500, 3000, and 4500 nM). As a result, the possible hormetic effects of BHPF on regulating the HPT axis were revealed, in which low-dose BHPF positively affected the HPT axis while this regulation was inhibited as the dose increased. Underlying mechanism investigation suggested that BHPF disrupted myelination through affecting HPT axis including related genes expression and TH levels, thus causing neurotoxic characteristics. Collectively, this study provides the full understanding of the environmental impact of BHPF and its toxicity on living organisms, highlighting a substantial and generalized ongoing dose-response relationship with great implications for the usage and risk assessment of BHPF.
- Subjects :
- medicine.medical_specialty
Environmental Engineering
010504 meteorology & atmospheric sciences
Bisphenol
Central nervous system
Thyroid Gland
010501 environmental sciences
01 natural sciences
Phenols
Internal medicine
medicine
Environmental Chemistry
Animals
Benzhydryl Compounds
Waste Management and Disposal
Zebrafish
0105 earth and related environmental sciences
Fluorenes
biology
Mechanism (biology)
Hormesis
biology.organism_classification
Pollution
Hypothalamic–pituitary–thyroid axis
Endocrinology
medicine.anatomical_structure
Toxicity
Neuron differentiation
Plastics
Subjects
Details
- ISSN :
- 18791026
- Volume :
- 776
- Database :
- OpenAIRE
- Journal :
- The Science of the total environment
- Accession number :
- edsair.doi.dedup.....1f6fdf3b25968df47e577445c7b7e336