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MEDICAL HISTORY AND THE RISK OF MULTIPLE-MYELOMA
- Source :
- British Journal of Cancer
- Publication Year :
- 1991
-
Abstract
- The relationship between various diseases and immunisations and the risk of multiple myeloma was analysed using data from a hospital-based case-control study conducted in Northern Italy on 117 patients with multiple myeloma and 477 controls. Associations were observed for clinical history of scarlet fever (relative risk, RR = 2.0; 95% confidence interval, CI = 1.1-3.9), tuberculosis (RR = 2.3%; 95% CI = 0.9-5.7) and BCG immunisation (RR = 3.0; 95% CI = 1.4-6.4). The relative risk was 1.8 (95% CI = 0.9-3.5) for episodes of Herpes zoster infection, but most of the excess cases occurred within 10 years of diagnosis, suggesting that this might have been an early manifestation of the disease. No association emerged for common childhood viral infections or any other immunisation practice. When various classes of infectious or inflammatory diseases were grouped together according to their aetiology, there was a significant positive association with chronic bacterial illnesses (RR = 1.8; 95% CI = 1.1-2.8), and the relative risk estimates increased with the number of bacterial diseases. The trend in risk with number of diseases was significant (chi 21 = 4.5, P = 0.03). A negative association was found between allergic conditions and risk of multiple myeloma (RR = 0.6; 95% CI = 0.3-1.0).
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Disease
Risk Factors
Internal medicine
medicine
Humans
Medical history
Risk factor
Multiple myeloma
Aged
business.industry
Case-control study
Bacterial Infections
Middle Aged
medicine.disease
Confidence interval
Italy
Oncology
Virus Diseases
Case-Control Studies
Relative risk
Immunology
Etiology
Female
Immunization
Multiple Myeloma
business
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....1f6d8c8652d99a1817b8d459393f8d83