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Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis
- Source :
- Antimicrobial Agents and Chemotherapy, Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2016, 60 (1), pp.662-665. ⟨10.1128/AAC.02265-15⟩, Antimicrobial Agents and Chemotherapy, 2016, 60 (1), pp.662-665. ⟨10.1128/AAC.02265-15⟩
- Publication Year :
- 2015
-
Abstract
- Treatment of Candida glabrata cystitis remains a therapeutic challenge, and an antifungal combination using flucytosine is one option. We describe two patients with refractory C. glabrata cystitis who failed flucytosine combined with caspofungin with early-acquired high-level resistance to flucytosine due to nonsense mutations in the FUR1 gene. Rapidly acquired flucytosine resistance with microbiological failure should discourage combination of caspofungin and flucytosine during urinary candidiasis.
- Subjects :
- 0301 basic medicine
Male
Antifungal Agents
[SDV]Life Sciences [q-bio]
Flucytosine
Gene Expression
adult patients
Candida glabrata
Drug resistance
Gastroenterology
chemistry.chemical_compound
Echinocandins
Caspofungin
Cystitis
Nucleobase Transport Proteins
Medicine
5-fluorocytosine
Pharmacology (medical)
Treatment Failure
Fungal protein
biology
Fungal genetics
Candidiasis
3. Good health
Infectious Diseases
Codon, Nonsense
Drug Therapy, Combination
Female
medicine.drug
medicine.medical_specialty
Combination therapy
030106 microbiology
Molecular Sequence Data
Urinary Bladder
albicans
Fungal Proteins
03 medical and health sciences
Lipopeptides
Pharmacotherapy
Drug Resistance, Fungal
Mechanisms of Resistance
Internal medicine
Humans
Aged
Pharmacology
Base Sequence
business.industry
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
bacterial infections and mycoses
chemistry
business
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 60
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy
- Accession number :
- edsair.doi.dedup.....1f61ee4226d0ef662eca955b6abe712c