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Preventive potential of body mass reduction to lower cardiovascular risk: the Italian Progetto Cuore Study
- Publication Year :
- 2008
-
Abstract
- Objective: To estimate effects of weight change on incidence of major cardiovascular events in the Italian population-based Progetto CUORE. Methods: Prospective observation in 12 Italian population-based cohorts on etiology of cardiovascular disease. Twenty-thousand six-hundred-forty-seven men and women aged 35-69years without previous CVD, examined at baseline between 1984 and 1993 and followed for median time 8.5years, with validated first cardiovascular events. Standardised anthropometric variables, lifestyle and biochemical risk factors for CVD; major cardiovascular events as end-points. Results: Linear regression between BMI and major CVD risk factors was combined with Cox coefficients from a prediction model of CVD, CHD and stroke using major risk factors as dependent variables. Estimated cardiovascular risk reductions with BMI lowered by 1 to 3U were: for men 3.8% to 10.9% for all cardiovascular events, 4.2% to 12.1% for CHD, and 2.3% to 6.9% for stroke; for women 2.8% to 8.1% for all cardiovascular events, 3.4% to 9.8% for CHD, and 2.1% to 6.2% for stroke. Conclusions: Body weight level influences cardiovascular disease risk in the Italian population. © 2008 Elsevier Inc. All rights reserved.
- Subjects :
- Adult
Male
medicine.medical_specialty
Epidemiology
BMI, cardiovascular risk
Disease
Body Mass Index
Cohort Studies
Risk Factors
Weight loss
Internal medicine
Weight Loss
medicine
Humans
Obesity
cardiovascular diseases
Stroke
Aged
business.industry
Incidence (epidemiology)
Weight change
Public Health, Environmental and Occupational Health
Middle Aged
Anthropometry
medicine.disease
Cardiovascular Diseases
Cardiology
Female
medicine.symptom
business
Risk Reduction Behavior
Body mass index
Cohort study
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1f61784347743fba5cd6aff8418b377e