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Hybrid Nanogels with Physical and Chemical Cross-Linking Structures as Nanocarriers
- Source :
- Macromolecular Bioscience. 5:710-716
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Polymerizable nanogels were prepared by self-assembly of cholesteryl group-bearing pullulan (CHP) with methacryloyl groups (CHPMA). The CHPMA nanogel was polymerized with 2-methacryloyloxyethyl phosphorylcholine (MPC) by radical polymerization in dilute aqueous solution. The solution properties of the polymers in water were investigated by TEM, SEC-MALS, and fluorescence quenching technique. Monodispersed hybrid nanogels of CHPMA-MPC (CM nanogels) (25-30 nm in radius of gyration) were obtained by using CHPMA nanogel as a seed-nanogel. CM nanogels have a dual cross-linking structure that is physically cross-linked with the cholesteryl groups and chemically cross-linked with the MPC polymer chains. CM nanogels trap heat-denatured carbonic anhydrase B (CAB) and prevent their aggregations. The nanogels maintained the ability of trapping and releasing enzymes by host-guest interaction of cholesteryl group and cyclodextrin.
- Subjects :
- chemistry.chemical_classification
Drug Carriers
Aqueous solution
Polymers and Plastics
Cyclodextrin
Polymers
Chemistry
Phosphorylcholine
Radical polymerization
Hydrogels
Bioengineering
Pullulan
Polymer
Nanostructures
Biomaterials
chemistry.chemical_compound
Cholesterol
Polymerization
Polymer chemistry
Materials Chemistry
Methacrylates
Glucans
Prepolymer
Biotechnology
Nanogel
Subjects
Details
- ISSN :
- 16165195 and 16165187
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Macromolecular Bioscience
- Accession number :
- edsair.doi.dedup.....1f5208323860e831c3e72e27c40973f5