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Association analysis of polymorphisms in six keratin genes with wool traits in sheep
- Source :
- Asian-Australasian Journal of Animal Sciences, Asian-Australasian Journal of Animal Sciences, Vol 31, Iss 6, Pp 775-783 (2018)
- Publication Year :
- 2018
- Publisher :
- Asian Australasian Association of Animal Production Societies, 2018.
-
Abstract
- Objective The purpose of this study was to investigate the genetic effects of six keratin (KRT) genes on the wool traits of 418 Chinese Merino (Xinjiang type) (CMXT) individuals. Methods To explore the effects and association of six KRT genes on sheep wool traits, The polymerase chain reaction-based single-strand conformation polymorphism (PCR-SSCP), DNA sequencing, and the gene pyramiding effect methods were used. Results We report 20 mutation sites (single-nucleotide polymorphisms) within the six KRT genes, in which twelve induced silent mutations; five induced missense mutations and resulted in Ile→Thr, Glu→Asp, Gly→Ala, Ala→Ser, Se→His; two were nonsense mutations and one was a same-sense mutation. Association analysis showed that two genotypes of the KRT31 gene were significantly associated with fiber diameter (p
- Subjects :
- 0301 basic medicine
Silent mutation
Candidate gene
Wool Traits
Population
Nonsense mutation
lcsh:Animal biochemistry
Locus (genetics)
Biology
Article
03 medical and health sciences
Genotype
Polymorphism
education
lcsh:QP501-801
Gene
lcsh:SF1-1100
Genetic association
Genetics
Chinese Merino (Xinjiang Type)
education.field_of_study
0402 animal and dairy science
04 agricultural and veterinary sciences
Animal Breeding and Genetics
040201 dairy & animal science
030104 developmental biology
Keratin
Combined Genotype
Animal Science and Zoology
lcsh:Animal culture
Food Science
Subjects
Details
- ISSN :
- 19765517 and 10112367
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Asian-Australasian Journal of Animal Sciences
- Accession number :
- edsair.doi.dedup.....1f2e806c3d780af009598f86644254db