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EGFR Somatic Mutations in Lung Tumors: Radon Exposure and Passive Smoking in Former- and Never-Smoking U.S. Women
- Source :
- Cancer Epidemiology, Biomarkers & Prevention. 21:988-992
- Publication Year :
- 2012
- Publisher :
- American Association for Cancer Research (AACR), 2012.
-
Abstract
- Background: Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis when treated with EGFR inhibitors. We hypothesized that EGFR mutations may be related to residential radon or passive tobacco smoke. Methods: This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smokers from Missouri with detailed exposure assessments. The relationship with passive smoking was also examined in never-smoking female lung cancer cases from the Mayo clinic. Results: Overall, the frequency of EGFR mutation was 41% [95% confidence interval (CI), 32%–49%]. Neither radon nor passive-smoking exposure was consistently associated with EGFR mutations in lung tumors. Conclusions: The results suggest that EGFR mutations are common in female, never-smoking lung cancer cases from the United States, and EGFR mutations are unlikely due to exposure to radon or passive smoking. Cancer Epidemiol Biomarkers Prev; 21(6); 988–92. ©2012 AACR.
- Subjects :
- Oncology
medicine.medical_specialty
Lung Neoplasms
Passive smoking
Epidemiology
Somatic cell
Population
medicine.disease_cause
Article
Tobacco smoke
Internal medicine
Humans
Medicine
education
Lung cancer
Aged
EGFR inhibitors
education.field_of_study
Missouri
Lung
business.industry
Smoking
Middle Aged
Prognosis
medicine.disease
Confidence interval
respiratory tract diseases
ErbB Receptors
medicine.anatomical_structure
Radon
Case-Control Studies
Mutation
Immunology
Female
Tobacco Smoke Pollution
business
Subjects
Details
- ISSN :
- 15387755 and 10559965
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Cancer Epidemiology, Biomarkers & Prevention
- Accession number :
- edsair.doi.dedup.....1f150c9f6c9fcfaed437f60f4215d912