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Dopamine D2 receptor density remains constant in treated Parkinson's disease
- Source :
- Annals of Neurology. 19:487-492
- Publication Year :
- 1986
- Publisher :
- Wiley, 1986.
-
Abstract
- D2 dopamine receptor densities were measured in postmortem samples of the caudate nucleus and putamen from 36 parkinsonian patients. The relationship between the age of the patient, duration of the disease, and duration of L-dopa therapy versus density of brain D2 dopamine receptors was examined using [3H]spiperone. Receptor density in parkinsonian tissues was constant over the age range of 56 to 90 years, as was the case for control tissues. Density did not change with duration of disease up to 24 years. Treatment with L-dopa did not cause progressive reduction in receptor density. The diminished clinical response in the final stages of Parkinson's disease is not due to receptor dropout, and must depend on other factors.
- Subjects :
- Male
medicine.medical_specialty
Spiperone
Time Factors
Parkinson's disease
Caudate nucleus
Disease
Receptors, Dopamine
Levodopa
Internal medicine
Dopamine receptor D2
medicine
Humans
Receptor
Aged
Receptors, Dopamine D2
business.industry
Putamen
Age Factors
Parkinson Disease
Middle Aged
medicine.disease
nervous system diseases
Endocrinology
Neurology
Dopamine receptor
Female
Neurology (clinical)
Caudate Nucleus
business
medicine.drug
Subjects
Details
- ISSN :
- 15318249 and 03645134
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi.dedup.....1f089a7884c782e068fe4803d0543205