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PhyloOncology: Understanding cancer through phylogenetic analysis
- Source :
- Biochim Biophys Acta Rev Cancer
- Publication Year :
- 2016
-
Abstract
- Despite decades of research and an enormity of resultant data, cancer remains a significant public health problem. New tools and fresh perspectives are needed to obtain fundamental insights, to develop better prognostic and predictive tools, and to identify improved therapeutic interventions. With increasingly common genome-scale data, one suite of algorithms and concepts with potential to shed light on cancer biology is phylogenetics, a scientific discipline used in diverse fields. From grouping subsets of cancer samples to tracing subclonal evolution during cancer progression and metastasis, the use of phylogenetics is a powerful systems biology approach. Well-developed phylogenetic applications provide fast, robust approaches to analyze high-dimensional, heterogeneous cancer data sets. This article is part of a Special Issue entitled: Evolutionary principles - heterogeneity in cancer?, edited by Dr. Robert A. Gatenby.
- Subjects :
- 0301 basic medicine
Cancer Research
Heredity
Time Factors
Systems biology
Biology
Bioinformatics
Somatic evolution in cancer
Article
Metastasis
Evolution, Molecular
03 medical and health sciences
Phylogenetics
Neoplasms
Genetics
medicine
Biomarkers, Tumor
Animals
Humans
Genetic Predisposition to Disease
Cancer biology
Phylogeny
Phylogenetic tree
Models, Genetic
Systems Biology
Cancer
Genomics
medicine.disease
Data science
Adaptation, Physiological
Cancer data
Pedigree
Gene Expression Regulation, Neoplastic
030104 developmental biology
Cell Transformation, Neoplastic
Phenotype
Oncology
Mutation
Genetic Fitness
Algorithms
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Biochim Biophys Acta Rev Cancer
- Accession number :
- edsair.doi.dedup.....1f0053ca6c4220cbcc6ebf6ca37d6985