Quantifying biomarkers of axonal degeneration in early glaucoma to find the disc at risk

To evaluate regional axonal-related parameters as a function of disease stage in primary open angle glaucoma (POAG) and visual field (VF) sensitivity. Spectral domain optical coherence tomography was used to acquire 20° scans of POAG (n = 117) or healthy control (n = 52) human optic nerve heads (ONHs). Region specific and mean nerve fibre layer (NFL) thicknesses, border NFL and peripapillary NFL, minimum rim width (MRW)/ area (MRA) and prelamina thickness; and volume were compared across POAG disease stages and with visual field sensitivity. Differences identified between early glaucoma (EG), preperimetric glaucoma (PG) and control (C) ONHs included thinner PG prelamina regions than in controls (p p p = 0.049) compared to control eyes; and EG mean, and inferior and ST, border NFL was thinner than in PG (p p p = 0.023). MRW differences included: PG SN and inferior less than in controls (p p p = 0.127) and prelamina volume (p