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A Phase II trial of paclitaxel and topotecan with filgrastim in patients with recurrent or refractory glioblastoma multiforme or anaplastic astrocytoma
- Source :
- Journal of neuro-oncology. 71(3)
- Publication Year :
- 2005
-
Abstract
- Purpose: Therapy for high-grade gliomas remains unsatisfactory. Paclitaxel and topotecan have separately demonstrated activity against gliomas. We conducted a Phase II trial of these agents in combination with filgrastim (G-CSF) in patients with recurrent or refractory glioblastoma multiforme or anaplastic astrocytoma.Patients and Methods: Adult patients with radiographic evidence of recurrent or progressive tumor following primary therapy were eligible for study. Patients received paclitaxel 175 mg/m2 IV over 3 h on day 1 and topotecan 1.0 mg/m 2 IV over 30 min on days 1–5. Filgrastim 5 μg/kg was given days 6–14 for neutrophil support. Treatment cycles were repeated every 21 days.Results: Twenty patients were enrolled on study, and seventeen were considered evaluable for response. Two patients (12/%) exhibited partial remission and seven patients (41/%) exhibited stable disease in response to therapy. Hematologic toxicity was common with 25 /% of patients experiencing grade III or IV leukopenia despite G-CSF support. Two patients died of infectious complications on protocol, prompting suspension of further accrual.Conclusion: Paclitaxel and topotecan with G-CSF support exhibits modest activity in adults with recurrent or refractory glioblastoma and anaplastic astrocytoma. The significant hematotoxicity encountered, however, cannot justify further investigation of this combination in patients with high grade brain tumors.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Filgrastim
Paclitaxel
Astrocytoma
Disease-Free Survival
Central nervous system disease
chemistry.chemical_compound
Refractory
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Granulocyte Colony-Stimulating Factor
medicine
Humans
Aged
Leukopenia
business.industry
Brain Neoplasms
Anemia
Middle Aged
medicine.disease
Thrombocytopenia
Recombinant Proteins
Surgery
Treatment Outcome
Neurology
chemistry
Drug Resistance, Neoplasm
Topotecan
Female
Neurology (clinical)
medicine.symptom
Neoplasm Recurrence, Local
business
Glioblastoma
medicine.drug
Anaplastic astrocytoma
Subjects
Details
- ISSN :
- 0167594X
- Volume :
- 71
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neuro-oncology
- Accession number :
- edsair.doi.dedup.....1eeffd03f18cc1a6482fdd23aef887a8