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Insulinomimetic Zinc(II) Complexes with Natural Products: In Vitro Evaluation and Blood Glucose Lowering Effect in KK-Ay Mice with Type 2 Diabetes Mellitus
- Source :
- Chemical and Pharmaceutical Bulletin. 51:1006-1008
- Publication Year :
- 2003
- Publisher :
- Pharmaceutical Society of Japan, 2003.
-
Abstract
- In vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(-)-quinic acid (qui), were found in rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. Based on the results, the blood glucose lowering effect in KK-A(y) mice with type 2 diabetes mellitus was observed by daily i.p. injections of a monomeric zinc(II) complex, Zn(qui)(2), for 13 d.
- Subjects :
- Blood Glucose
medicine.medical_specialty
medicine.medical_treatment
Drug Evaluation, Preclinical
chemistry.chemical_element
Zinc
Mice
chemistry.chemical_compound
Betaine
Internal medicine
Diabetes mellitus
Drug Discovery
medicine
Animals
Insulin
Pancreatic hormone
chemistry.chemical_classification
Biological Products
Fatty acid
Type 2 Diabetes Mellitus
Biological activity
General Chemistry
General Medicine
medicine.disease
Rats
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Zinc Compounds
Subjects
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....1ee679d42f447b2740ef15bbe297e925