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The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol

Authors :
J. Stocks
T.L. Dormandy
Rosemary J. Sharp
J.M.C. Gutteridge
Source :
Clinical Science. 47:223-233
Publication Year :
1974
Publisher :
Portland Press Ltd., 1974.

Abstract

1. The inhibitory (antioxidant) effect of serum on the autoxidation of tissue polyunsaturated fatty acids has been investigated. 2. Dialysis studies, DEAE-cellulose chromatography, gel filtration, immunoelectrophoresis and immunodiffusion experiments showed that this effect is the function of two serum protein fractions. 3. One fraction was identified as transferrin. The second fraction includes caeruloplasmin. 4. Studies with radioactively labelled α-tocopherol showed that serum tocopherol in the physiological concentration range contributes only marginally to the total antioxidant activity of serum. 5. These findings are discussed in the wider context of biological antioxidant protection.

Details

ISSN :
03010538
Volume :
47
Database :
OpenAIRE
Journal :
Clinical Science
Accession number :
edsair.doi.dedup.....1ed47675ace13923728ba7442d45201e
Full Text :
https://doi.org/10.1042/cs0470223