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The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol
- Source :
- Clinical Science. 47:223-233
- Publication Year :
- 1974
- Publisher :
- Portland Press Ltd., 1974.
-
Abstract
- 1. The inhibitory (antioxidant) effect of serum on the autoxidation of tissue polyunsaturated fatty acids has been investigated. 2. Dialysis studies, DEAE-cellulose chromatography, gel filtration, immunoelectrophoresis and immunodiffusion experiments showed that this effect is the function of two serum protein fractions. 3. One fraction was identified as transferrin. The second fraction includes caeruloplasmin. 4. Studies with radioactively labelled α-tocopherol showed that serum tocopherol in the physiological concentration range contributes only marginally to the total antioxidant activity of serum. 5. These findings are discussed in the wider context of biological antioxidant protection.
- Subjects :
- Adult
Immunodiffusion
Antioxidant
medicine.medical_treatment
Immunoelectrophoresis
Tritium
Antioxidants
Chromatography, DEAE-Cellulose
medicine
Humans
Vitamin E
Tocopherol
chemistry.chemical_classification
medicine.diagnostic_test
Autoxidation
Chemistry
Transferrin
Ceruloplasmin
Blood Proteins
General Medicine
Lipid Metabolism
Blood proteins
Biochemistry
Chromatography, Gel
Electrophoresis, Polyacrylamide Gel
Dialysis
Oxidation-Reduction
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 03010538
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Clinical Science
- Accession number :
- edsair.doi.dedup.....1ed47675ace13923728ba7442d45201e
- Full Text :
- https://doi.org/10.1042/cs0470223