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Secondary Neuroendocrine Carcinoma Following High-Dose Radiotherapy for Head and Neck Cancer: Report of Two Cases
- Source :
- Cureus
- Publication Year :
- 2016
- Publisher :
- Cureus, 2016.
-
Abstract
- Patients treated with radiation have an increased risk of developing second cancers, of which carcinomas, sarcomas, and hematological malignancies have most commonly been reported. Neuroendocrine carcinomas (NEC) are rarely reported in patients previously treated with radiation. Two patients, who had successfully undergone chemoradiotherapy for head and neck cancers at our institution, developed secondary NEC within the radiation field more than five years after the treatment. Both patients underwent curative-intent treatment of secondary malignancies, one with chemotherapy, radiation and surgery (Case 1) and the other with chemotherapy and surgery (Case 2). Both had no evidence of disease at a short follow-up of twelve months (Case 1), and three months (Case 2) after treatment. NEC can develop post-radiotherapy; a multidisciplinary approach is necessary to successfully treat these patients.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Disease
head and neck
03 medical and health sciences
Otolaryngology
0302 clinical medicine
medicine
neuroendocrine
Neuroendocrine carcinoma
In patient
Head and neck
secondary cancer
Chemotherapy
business.industry
Head and neck cancer
General Engineering
medicine.disease
Surgery
Radiation therapy
radiation
Oncology
030220 oncology & carcinogenesis
Radiation Oncology
030211 gastroenterology & hepatology
business
Chemoradiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 21688184
- Volume :
- 8
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cureus
- Accession number :
- edsair.doi.dedup.....1ecff922d7ab2f44b367aef0e0d637f8