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Pediatric Multiple Sclerosis
- Source :
- Seminars in neurology. 36(2)
- Publication Year :
- 2016
-
Abstract
- Pediatric multiple sclerosis (MS) is a chronic inflammatory neurologic disease that is challenging to diagnose and treat. Although there are many clinical parallels between pediatric-onset MS and adult-onset MS, there is also accumulating evidence of distinguishing clinical features that may, in part, arise from development-specific, neuroimmune processes governing MS pathogenesis in children. Here the authors describe the clinical features, diagnosis, and treatment of pediatric MS, with a particular focus on describing clinical features and highlighting new developments that promise a better understanding of pediatric MS pathogenesis. An important task that lies ahead for pediatric neurologists is better understanding the early gene-environment interaction that precipitates the first demyelinating event in pediatric MS. This area is of particular importance for understanding the MS etiology and the natural history of pediatric MS. Such understanding should in turn inform new developments in diagnostic tools, long-term therapies, and much-needed biomarkers. Such biomarkers are not only valuable for defining the disease onset, but also for monitoring both the treatment response and a disease evolution that spans multiple decades in children with MS.
- Subjects :
- medicine.medical_specialty
Treatment response
Disease onset
Multiple Sclerosis
business.industry
Multiple sclerosis
medicine.disease
Diagnostic tools
Natural history
03 medical and health sciences
0302 clinical medicine
Neurology
Physical therapy
Etiology
Medicine
Humans
030212 general & internal medicine
Neurology (clinical)
Neurologic disease
Age of onset
Age of Onset
business
Intensive care medicine
Child
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10989021
- Volume :
- 36
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Seminars in neurology
- Accession number :
- edsair.doi.dedup.....1ecac27fa26a0dccf6f4ebd72922ce72