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First experiences with intraoperative Levosimendan in pediatric cardiac surgery
- Source :
- European Journal of Pediatrics. 168:735-740
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Levosimendan is a calcium-sensitizing agent with effective inotropic properties. It has been shown to improve cardiac function, hemodynamic performance, and survival in adults with severe heart failure. However, the effect of Levosimendan in pediatric cardiac surgery has not yet been investigated. Thus, we report on our experience with the intraoperative application of Levosimendan in seven infants (body weight range 2.6-6.3 kg) with severe myocardial dysfunction after complex congenital heart surgery. During the administration of Levosimendan, the heart rate, mean arterial blood pressure, and central venous pressure did not change. The mean arterial lactate level significantly decreased 24 and 48 h after the first infusion compared to baseline. Central venous oxygen saturation increased significantly 24 and 48 h after the onset of Levosimendan infusion. We found intraoperatively administered Levosimendan to be well tolerated in the seven infants with severe myocardial dysfunction after complex congenital heart surgery. Levosimendan is a new rescue drug which has beneficial effects, even in pediatric cardiac surgery.
- Subjects :
- Heart Defects, Congenital
Cardiac function curve
Cardiac output
medicine.medical_specialty
Cardiotonic Agents
Heart disease
Transposition of Great Vessels
Cardiac Output, Low
Intraoperative Period
Postoperative Complications
Humans
Medicine
Lactic Acid
Cardiac Output
Cardiac Surgical Procedures
Infusions, Intravenous
Simendan
Retrospective Studies
business.industry
Hemodynamics
Hydrazones
Infant, Newborn
Central venous pressure
Infant
Heart
Levosimendan
Length of Stay
medicine.disease
Respiration, Artificial
Cardiac surgery
Oxygen
Pyridazines
Blood pressure
Anesthesia
Heart failure
Pediatrics, Perinatology and Child Health
business
medicine.drug
Subjects
Details
- ISSN :
- 14321076 and 03406199
- Volume :
- 168
- Database :
- OpenAIRE
- Journal :
- European Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....1ec898845c3874c16c61fccd509952d5