Back to Search
Start Over
Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy
- Source :
- European journal of obstetrics, gynecology, and reproductive biology. 224
- Publication Year :
- 2017
-
Abstract
- Objective The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). Study design This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed. Results A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP. Conclusion A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.
- Subjects :
- Adult
medicine.medical_specialty
Miscarriage
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Fetus
030219 obstetrics & reproductive medicine
Placental abruption
Obstetrics
business.industry
Area under the curve
Obstetrics and Gynecology
Gestational age
medicine.disease
Gestational diabetes
Pregnancy Complications
Reproductive Medicine
Case-Control Studies
Female
business
Cell-Free Nucleic Acids
Maternal Serum Screening Tests
Subjects
Details
- ISSN :
- 18727654
- Volume :
- 224
- Database :
- OpenAIRE
- Journal :
- European journal of obstetrics, gynecology, and reproductive biology
- Accession number :
- edsair.doi.dedup.....1ec1a28d2c06e8471a79e4bbc13424d1