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Resolution of possible acquired protein S deficiency after viral suppression in HIV infection
- Source :
- BMJ case reports. 14(11)
- Publication Year :
- 2023
-
Abstract
- Current literature suggests an increased risk of venous thromboembolism (VTE) in people living with HIV (PLWH) with poorly controlled viraemia and immunodeficiency. VTE treatment guidelines do not specifically address anticoagulation management in PLWH. We report a case of a 33-year-old woman diagnosed with an unprovoked pulmonary embolism (PE) and deemed protein S deficient. Three years later, she was diagnosed with AIDS. Antiretroviral therapy (ART) was promptly initiated with viral suppression and immune reconstitution within 12 months. Eight years after her initial PE, the patient self-discontinued warfarin. Multiple repeat protein S values were normal. ART without anticoagulation has continued for 3 years with no thrombotic events. This case describes a patient with VTE presumably secondary to undiagnosed HIV with possible consequent acquired protein S deficiency. Additional research is needed to understand the characteristics of PLWH with VTE who may warrant long-term anticoagulation as opposed to shorter courses.
- Subjects :
- Adult
Pediatrics
medicine.medical_specialty
Protein S Deficiency
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Protein S
Acquired immunodeficiency syndrome (AIDS)
Recurrence
Risk Factors
medicine
Humans
Viral suppression
Immunodeficiency
Acquired Protein S Deficiency
biology
business.industry
Warfarin
Anticoagulants
General Medicine
Venous Thromboembolism
medicine.disease
Pulmonary embolism
biology.protein
Female
business
Pulmonary Embolism
medicine.drug
Subjects
Details
- ISSN :
- 1757790X
- Volume :
- 14
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- BMJ case reports
- Accession number :
- edsair.doi.dedup.....1eb4ef527c1ffda06351713c8cc84ffb