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The ventral pallidum as a critical region for fatty acid amide hydrolase inhibition of nausea-induced conditioned gaping in male Sprague-Dawley rats
- Source :
- Neuropharmacology. 155:142-149
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Here we investigate the involvement of the ventral pallidum (VP) in the anti-nausea effect of fatty acid amide hydrolase (FAAH) inhibition with PF-3845, and examine the pharmacological mechanism of such an effect. We explored the potential of intra-VP PF-3845 to reduce the establishment of lithium chloride (LiCl)-induced conditioned gaping (a model of acute nausea) in male Sprague-Dawley rats. As well, the role of the cannabinoid 1 (CB1) receptors and the peroxisome proliferator-activated receptors-α (PPARα) in the anti-nausea effect of PF-3845 was examined. Finally, the potential of intra-VP GW7647, a PPARα agonist, to reduce acute nausea was also evaluated. Intra-VP PF-3845 dose-dependently reduced acute nausea by a PPARα mechanism (and not a CB1 receptor mechanism). Intra-VP administration of GW7647, similarly attenuated acute nausea. These findings suggest that the anti-nausea action of FAAH inhibition may occur in the VP, and may involve activation of PPARα to suppress acute nausea.
- Subjects :
- Male
0301 basic medicine
Basal Forebrain
Pyridines
medicine.medical_treatment
Pharmacology
Amidohydrolases
Rats, Sprague-Dawley
Ventral pallidum
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Oleoylethanolamide
0302 clinical medicine
Piperidines
Fatty acid amide hydrolase
medicine
Animals
Receptor
Palmitoylethanolamide
Chemistry
Phenylurea Compounds
Nausea
Anandamide
Rats
Butyrates
Infusions, Intraventricular
030104 developmental biology
Cannabinoid
Peroxisome proliferator-activated receptor alpha
Lithium Chloride
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00283908
- Volume :
- 155
- Database :
- OpenAIRE
- Journal :
- Neuropharmacology
- Accession number :
- edsair.doi.dedup.....1eac33478ca007ea28646f9f86ad5262