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Repair of large osteochondral defects in a beagle model with a novel type I collagen/glycosaminoglycan-porous titanium biphasic scaffold
- Source :
- Materials Science and Engineering: C. 33:3951-3957
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- The limited repair potential of articular cartilage, which hardly heals after injury or debilitating osteoarthritis, is a clinical challenge. The aim of this work was to develop a novel type I collagen (Col)/glycosaminoglycan (GAGs)-porous titanium biphasic scaffold (CGT) and verify its ability to repair osteochondral defects in an animal model with bone marrow stem cells (bMSCs) in the chondral phase. The biphasic scaffold was composed of Col/GAGs as chondral phasic and porous titanium as subchondral phasic. Twenty-four full-thickness defects through the articular cartilage and into the subchondral bone were prepared by drilling into the surface of the femoral patellar groove. Animals were assigned to one of the three groups: 1) CGT with bMSCs (CGTM), 2) only CGT, and 3) no implantation (control). The defect areas were examined grossly, histologically and by micro-CT. The most satisfied cartilage repairing result was in the CGTM group, while CGT alone was better than the control group. Abundant subchondral bone formation was observed in the CGTM and CGT groups but not the control group. Our findings demonstrate that a composite based on a novel biphasic scaffold combined with bMSCs shows a high potential to repair large osteochondral defects in a canine model.
- Subjects :
- Cartilage, Articular
Male
Materials science
X-ray microtomography
Bone Marrow Cells
Bioengineering
Osteoarthritis
Collagen Type I
Biomaterials
Glycosaminoglycan
Dogs
medicine
Animals
Cell Proliferation
Glycosaminoglycans
Titanium
Wound Healing
Staining and Labeling
Tissue Scaffolds
Stem Cells
Cartilage
Bone Marrow Stem Cell
X-Ray Microtomography
Anatomy
medicine.disease
Disease Models, Animal
medicine.anatomical_structure
Mechanics of Materials
Cattle
Stem cell
Wound healing
Porosity
Type I collagen
Biomedical engineering
Subjects
Details
- ISSN :
- 09284931
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Materials Science and Engineering: C
- Accession number :
- edsair.doi.dedup.....1e8410701d96731fee84654eedb8df06