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Waitlist Mortality Decreases with Increased Use of Extended Criteria Donor Liver Grafts at Adult Liver Transplant Centers
- Source :
- American Journal of Transplantation. 7:1265-1270
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Extended criteria donor (ECD) liver allografts are often allocated to less severely ill liver transplant (LT) candidates who are at a relatively lower risk of pretransplant mortality, but it is not clear that the use of ECD allografts will decrease center waitlist mortality (WLM). Individual patient data from the UNOS OPTN database (2002-2005) were aggregated to obtain center-specific data. Deceased donor allografts with any of the following characteristics were defined as ECDs: from a donor with any of the criteria described by the New York State Department of Health Workgroup; or 12+ h of cold ischemia. Multivariate regression was used to examine the relationship between WLM and ECD, non-ECD and LDLT use after adjusting for candidate severity of illness. A total of 3555 ECD transplants, 11,660 standard criteria donor (SCD) transplants, and 717 LDLTs were performed at 100 centers during this period. The model demonstrated that SCD and ECD LTs were inversely correlated with a center's WLM (beta=-0.242 and -0.221, respectively; p
- Subjects :
- Adult
medicine.medical_specialty
Tissue and Organ Procurement
Waiting Lists
genetic structures
Urology
Eligibility Determination
Extended criteria
Lower risk
Severity of Illness Index
Risk Factors
Severity of illness
Epidemiology
medicine
Humans
Transplantation, Homologous
Immunology and Allergy
Pharmacology (medical)
Survival analysis
Transplantation
business.industry
Liver Diseases
Patient Selection
Middle Aged
Models, Theoretical
Survival Analysis
Tissue Donors
United States
Liver Transplantation
Surgery
Multivariate Analysis
Waitlist mortality
Living donor liver transplantation
business
Subjects
Details
- ISSN :
- 16006135
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- American Journal of Transplantation
- Accession number :
- edsair.doi.dedup.....1e6f7fad372871ae52fb409db04e0637