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Synthesis of trifluoromethyl-containing vicinal diamines by asymmetric decarboxylative mannich addition reactions
- Source :
- The Journal of organic chemistry. 80(6)
- Publication Year :
- 2015
-
Abstract
- Herein is reported a study of asymmetric decarboxylative Mannich addition reactions between (Ss)-N-t-butylsulfinyl-3,3,3-trifluoroacetaldimine and Schiff bases derived from various aldehydes and lithium 2,2-diphenylglycinate. These reactions proceed with excellent diastereoselectivities and good chemical yields, providing a practical method for preparation of trifluoromethyl-containing vicinal diamines. The procedures can be conducted under convenient conditions, rendering this approach of high synthetic value.
Details
- ISSN :
- 15206904
- Volume :
- 80
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Journal of organic chemistry
- Accession number :
- edsair.doi.dedup.....1e5f76f7162e76bd192421629ba9c17c