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Serum N-Telopeptide and Bone-Specific Alkaline Phosphatase Levels in Patients With Osteonecrosis of the Jaw Receiving Bisphosphonates for Bone Metastases
- Source :
- Journal of Oral and Maxillofacial Surgery. 70:2768-2775
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Purpose Oversuppression of bone turnover can be a critical factor in the pathogenesis of osteonecrosis of the jaw (ONJ). We investigated N-telopeptide of type I collagen (NTX) and bone-specific alkaline phosphatase (BAP) as potential predictors of ONJ onset. Patients and Methods Patients with ONJ and available stored serum were identified retrospectively from the institutional databases. Four approximate points were examined: point of ONJ diagnosis and 12, 6, and 1 month before the diagnosis. NTX and BAP were measured using enzyme-linked immunosorbent assays and examined as possible predictors of ONJ. Results From March 1998 to September 2009, we identified 122 patients with ONJ. Of these, 56 (46%) had one or more serum samples available. Overall, 55 patients (98%) received bisphosphonates. Using the exact dates, no obvious patterns in either NTX or BAP were noted. Similarly, using the ordinal points, no evidence of suppression of NTX or BAP over time was seen. The consecutive median values were as follows: The median NTX values were 8.0 nmol/L (range 3.8 to 32.9) at 12 months before ONJ; 9.5 nmol/L (range 4.7 to 42.7) at 6 months; 9.5 nmol/L (range 4.5 to 24.6) at 1 month, and 10.4 nmol/L (range 4.4 to 32.5) at the ONJ diagnosis. The median BAP values were BAP 18.0 U/L (range 7.0 to 74) at 12 months before ONJ; 18.0 U/L (range 4.0 to 134) at 6 months; 14.0 U/L (range 4.0 to 132) at 1 month, and 18.0 U/L (range 0.7 to 375) at the ONJ diagnosis. Only 2 patients (4%) had NTX and 17 (30%) had BAP below the normal range at the ONJ diagnosis. Conclusions In the present large retrospective study, no trends were seen in the NTX and BAP levels before the ONJ diagnosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Bone Neoplasms
Breast Neoplasms
Bone Specific Alkaline Phosphatase
Gastroenterology
Bone and Bones
Collagen Type I
Bone remodeling
N-terminal telopeptide
Internal medicine
Humans
Medicine
In patient
Aged
Retrospective Studies
Aged, 80 and over
Bone Density Conservation Agents
Diphosphonates
business.industry
Prostatic Neoplasms
Retrospective cohort study
Middle Aged
Alkaline Phosphatase
Serum samples
medicine.disease
Surgery
Otorhinolaryngology
Alkaline phosphatase
Bisphosphonate-Associated Osteonecrosis of the Jaw
Female
Oral Surgery
Peptides
business
Osteonecrosis of the jaw
Biomarkers
Follow-Up Studies
Forecasting
Subjects
Details
- ISSN :
- 02782391
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Journal of Oral and Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....1e5f107170ca74db3286c5684b66529a