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First trimester serum biomarkers in pregnancies complicated with placental chronic inflammation
- Source :
- European Journal of Obstetrics & Gynecology and Reproductive Biology, European Journal of Obstetrics & Gynecology and Reproductive Biology, Elsevier, 2019, 241, pp.119-125. ⟨10.1016/j.ejogrb.2019.08.014⟩
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- This study aimed at determining if first trimester serum biomarkers could predict adverse pregnancy outcomes associated with villitis (VUE) and chronic intervillositis of unknown etiology (CIUE).Between January 2013 and June 2018, we selected from pathology department files placentas with VUE or CIUE associated with VUE and control placentas with available first trimester Down syndrome screening results. First trimester PAPP-A and βhCG levels were recorded. Placental growth factor (PlGF) levels were measured in patients with an available first trimester serum sample. Histological findings in placentas, course of pregnancies and newborns' characteristics were compared between cases and controls.78 cases and 75 controls were included. In cases, there were 21,8% intrauterine growth restriction (IUGR), 30,8% small for gestational age (SGA). Compared to controls, placentas from cases were smaller (425 g [IQR 370-480] vs 460 g [IQR 390-523], p = 0,03), showed more maternal vascular malperfusion features (79,5% vs 22,7%, p 0,0001) and more fetal vascular malperfusion features (33,3% vs 12%, p = 0,002). Cases had lower PlGF (29,74 pg/ml [IQR 19,74-36,17] vs 36,37 pg/ml [IQR 27,36-49,13], p = 0,007) and βhCG levels (0,74 MoM [IQR 0,53-1,12] vs 1,00 MoM [IQR 0,72-1,53], p = 0,002) than controls. These differences resulted from lower PlGF levels in VUE patients compared to CIUE associated with VUE patients and controls (28,35 vs 34,05 and 36,37 pg/ml, p = 0,01) and from lower βhCG levels in CIUE associated with VUE patients compared to VUE patients and controls (0,65 vs 0,86 and 1, p = 0,005).Low first trimester PlGF levels in cases, especially in VUE patients, suggest that reduced angiogenesis is involved in adverse pregnancy outcomes related to VUE.
- Subjects :
- Adult
Placental growth factor
medicine.medical_specialty
Placenta Diseases
Placenta
[SDV]Life Sciences [q-bio]
Intrauterine growth restriction
Inflammation
03 medical and health sciences
0302 clinical medicine
Pregnancy
Serum biomarkers
Humans
Medicine
030212 general & internal medicine
Pregnancy outcomes
Retrospective Studies
030219 obstetrics & reproductive medicine
business.industry
Obstetrics
Obstetrics and Gynecology
medicine.disease
3. Good health
[SDV] Life Sciences [q-bio]
Pregnancy Trimester, First
First trimester
Reproductive Medicine
Etiology
Small for gestational age
Female
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 03012115
- Volume :
- 241
- Database :
- OpenAIRE
- Journal :
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Accession number :
- edsair.doi.dedup.....1e5bcc164bc9e84897b78f90cc6f68a7