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Prognostic significance of body mass index in breast cancer patients with hormone receptor-positive tumours after curative surgery
- Source :
- Clinical and investigative medicine. Medecine clinique et experimentale. 36(6)
- Publication Year :
- 2013
-
Abstract
- Purpose: Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance of body mass index (BMI) in hormone receptor-positive, operable breast cancer. Methods: In this retrospective cohort study, 1,192 consecutive patients with curative resection of primary breast cancer were enrolled. Patients were assigned to two groups according to BMI: normal or underweight (BMI < 23.0 kg/m2) and overweight or obese (BMI ≥23.0 kg/m2). Associations among BMI and clinicopathological characteristics and prognosis of patients were assessed. Results: A high BMI was significantly (P < 0.01) correlated with age, nodal stage, ALNR, ER positivity, PR positivity and menopausal status at diagnosis. Univariate analysis revealed that BMI, pathologic T stage, nodal stage, axillary lymph node ratio (ALNR) and adjuvant radiotherapy history were significantly (P < 0.05) associated with disease-free survival and overall survival, irrespective of tumour hormone receptor status. Multivariate analysis revealed BMI as an independent prognostic factor in all cases and in hormone receptor-positive cases. Conclusion: A high BMI (≥23.0 kg/m^2) is independently associated with poor prognosis in hormone receptor-positive breast cancer.
- Subjects :
- Oncology
Adult
medicine.medical_specialty
Breast Neoplasms
Overweight
Body Mass Index
Breast cancer
Internal medicine
Medicine
Humans
Obesity
Stage (cooking)
Retrospective Studies
Univariate analysis
business.industry
nutritional and metabolic diseases
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Hormone receptor
Female
medicine.symptom
Underweight
business
Body mass index
Subjects
Details
- ISSN :
- 14882353
- Volume :
- 36
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Clinical and investigative medicine. Medecine clinique et experimentale
- Accession number :
- edsair.doi.dedup.....1e58a955242316438e460802e9929619