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Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products
- Source :
- Natural product reports. 36(3)
- Publication Year :
- 2018
-
Abstract
- Covering: up to mid-2018 Pyridoxal 5'-phosphate (PLP) is a versatile organic cofactor used to catalyze diverse reactions on amino acid, oxoacid, and amine substrates. Here we review the reactions catalyzed by PLP-dependent enzymes, highlighting enzymes reported in the natural product biosynthetic literature. We describe enzymes that catalyze transaminations, Claisen-like condensations, and β- and γ-eliminations and substitutions, along with epimerizations, decarboxylations, and transaldolations. Finally, we describe a newly reported group of O2-, PLP-dependent enzymes. Altogether, natural product biosynthesis showcases the incredible versatility of PLP-dependent transformations for building chemical complexity.
- Subjects :
- Lactams
Stereochemistry
Lipoproteins
010402 general chemistry
01 natural sciences
Biochemistry
Cofactor
chemistry.chemical_compound
Biosynthesis
Drug Discovery
Pyridoxal phosphate
Pyridoxal
chemistry.chemical_classification
Biological Products
Natural product
biology
010405 organic chemistry
Pactamycin
Organic Chemistry
Imidazoles
Thiones
0104 chemical sciences
Amino acid
Thiazoles
Enzyme
chemistry
Pyridoxal Phosphate
Oxoacid
biology.protein
lipids (amino acids, peptides, and proteins)
Macrolides
Oligopeptides
Saxitoxin
Subjects
Details
- ISSN :
- 14604752
- Volume :
- 36
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Natural product reports
- Accession number :
- edsair.doi.dedup.....1e52e564e38e5510fea0fe0343bce88b