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A leukaemic cell mutant with a thermolabile alanyl-transfer RNA synthetase
- Source :
- Nature. 257:813-815
- Publication Year :
- 1975
- Publisher :
- Springer Science and Business Media LLC, 1975.
-
Abstract
- IT may be of great help in the elucidation of regulatory systems in mammalian cells if we could isolate temperature-conditional mutants and identify their mutated functions. I report here that a temperature-sensitive mutant of L5178Y murine leukaemic cells has a thermolabile L-alanyl-tRNA synthetase.
- Subjects :
- Leukemia, Experimental
Multidisciplinary
Alanine-tRNA Ligase
Mutant
Cell
Temperature
Alanine Transaminase
Metabolism
Biology
medicine.disease
Molecular biology
Cell Line
Amino Acyl-tRNA Synthetases
Transfer RNA Synthetase
medicine.anatomical_structure
Biochemistry
Mutation
medicine
Animals
Neoplasm
Thermolabile
Subjects
Details
- ISSN :
- 14764687 and 00280836
- Volume :
- 257
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....1e4e38c8f6f7429b6e4bfcd77beae1cb