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Ketamine ameliorates depressive-like behaviors and immune alterations in adult rats following maternal deprivation
- Source :
- Neuroscience Letters. 584:83-87
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- A growing body of evidence points toward an association between the glutamatergic system, as well as immune system dysregulation and major depression. So, the present study was aimed at evaluating the behavioral and molecular effects of the ketamine, an antagonist of the N-methyl-D-aspartate (NMDA) receptor of glutamate in maternally deprived adult rats. In deprived rats treated with saline, we observed an increase in the immobility time; however, ketamine treatment reversed this effect, decreasing immobility time. In addition, maternal deprivation induced an increase in cytokines: TNF-α and IL-1 in serum, and in IL-6 in serum and cerebrospinal fluid (CSF). Interestingly, ketamine treatment reduced the levels of all the cytokines in deprived rats. In conclusion, these findings further support a relationship between immune activation and depression. Considering the action of ketamine, this study suggested that antagonists of the NMDA receptor, such as ketamine, could exert their effects by modulation of the immune system.
- Subjects :
- Male
medicine.medical_specialty
Glutamatergic
Immune system
Internal medicine
medicine
Animals
Ketamine
Rats, Wistar
Receptor
Maternal deprivation
Depression
Interleukin-6
Tumor Necrosis Factor-alpha
Maternal Deprivation
General Neuroscience
Antagonist
Glutamate receptor
Antidepressive Agents
Endocrinology
Cytokines
NMDA receptor
Female
Psychology
Interleukin-1
medicine.drug
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 584
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....1e4e0d105344b4ec70738c705b272cf1
- Full Text :
- https://doi.org/10.1016/j.neulet.2014.10.022